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Novel biological markers for diagnosis and prognosis of poisoning with organophosphates, with special reference to acylpeptide hydrolase

Stanislav Yanev

Abstract

Finding specific markers for changes in the biological systems after taking drugs or the consequences of exposure to toxic chemicals in the environment are increasingly important. Herein, the available biomarkers for documenting the interaction of organophosphorus compounds (neuroparalytic agents, pesticides, and drug preparations) with the biological systems as inhibition of cholinesterase group enzymes (AChE and BuChE) are reviewed. The advantages in the study of the activity of acylpeptide hydrolase in the blood for prevention and diagnosis of the organism changes after interaction with an organophosphorus compound are highlighted.

Keywords

organophosphates, cholinesterases, acylpeptide hydrolase, pesticides, biomarkers

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References

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DOI: http://dx.doi.org/10.14748/bmr.v33.9118

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About The Author

Stanislav Yanev
Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia
Bulgaria

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