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Bulgarian Review of Ophthalmology

Objective Assessment of Meibomian Gland Loss and Investigation of a Correlation with Non-Invasive Tear Break up Time using OCULUS Keratograph 5m.

A. Vassilev, I. Chernodrinska, St. Kostova, M. Slavkova, Y. Zdravkov

Abstract

The tear film consists of mucus and aqueous phase produced by the Goblet cells and tear glands and overlaying oily layer which is result of the function of Meibomian glands. The tear film in Dry eye syndrome is damaged either through tear deficiency or through its excessive evaporation. It is considered that the Meibomian gland dysfunction is the main reason for Dry eye disease and can result in tear film instability, damage of the epithelial surface cells, chronic blepharitis, subjective discomfort, contact lenses intolerance and others.

Aim of the current study is the investigation of Meibomian glands in patients of different ages by determination of the percent Meibomian gland loss (MGL) for the upper and lower eyelid and the correlation analysis between MGL and non-invasive tear break up time (NIBUT).

Materials and methods: The Meibomian gland loss and NIBUT were determined by the corneal Keratograph Oculus 5m. 285 eyes were included of patients ranging from 20 to 90 years of age. The meibographic images were subsequently analyzed with Image J software. The statistical analysis regarding Pearson correlation, linear regression and ANOVA was performed with IBM SPSS v.19.0.0

Results and conclusions: A weak but statistically significant correlation was determined between Meibomian glands loss and the non-invasive tear break up time. The patients` age turns out to be the most important factor, while the gender is of no such significance. Besides a difference was estimated between the percent of lower and upper eyelid Meibomian gland loss although there is a correlation between them.

Keywords

NIBUT; Meibomian gland loss; Corneal Keratography; Dry eye

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References

Arita R, Itoh K, Maeda et al. 2009. Proposed diagnostic criteria for obstructive meibomian gland dysfunction. Ophthalmology 116; 2058-2063 e1.

Arita R., Itoh K., Inoue K., Amano S. 2008. Non-contact infrared meibography to document age-related changes of the meibomian glands in a normal population. Ophthalmology, 115; 911-915.

Arita R., Minoura I., Morishige N., Shirakawa R., Fukuoka S., Asai K., Goto T., Imanaka T., Nakamura M. 2016. Development of definitive and reliable grading scales for Meibomian gland dysfunction. American Journal of Ophthalmology 169, 125-137

Arita R., Morishige N., Koh S., Shirakawa R., Kawashima M., Sakimoto T., Suzuki T., Tsubota K. 2015. Increased tear 􀃀 uid production as a compensatory response to Meibomian gland loss: a multicenter cross-sectional study. Ophthalmology 122, 925-933.

Ban Y, Shimazaki-Den S., Tsubota K., Shimazaki J. 2013 Morphological Evaluation of Meibomian Glands Using Noncontact Infrared Meibography; The Ocular Surface 11, 47-53

Bron AJ, Benjamin L, Snibson GR, 1991. Meibomian gland disease. Classification of lid changes. Eye 5 ; 395-411.

Erb C. 2012. Investigation of dry eye in Glaucoma and dry eye; Uni-Med Verlag AG, 24-36.

Labrie F. 2010. DHEA, important source of sex steroids in men and even more in women. Progress in Brain Research; 182:97-148

Mohidin N., Bay T.Ch., Yap M., 2002. Non-invasive tear break up time in normal Malays, Clin Exp Optom; 85, 37-41

Nichols JJ., Bernsten DA, Mitchell GL, Nichols KK. 2005. An assessment of grading scales for meibography images. Cornea 24 (4); 382-388.

Pult H., Nichols JJ. 2012 A review of meibography. Optometry and Vision Science 89, 760-769

Pult H., Riede- Pult B. 2012, Comparison of subjective grading and objective assessment in meibography; Contact Lens & Anterior Eye 36, 22-27

Sahin O., Kartal E., Taheri N. 2011. Meibomian gland dysfunction: Endocrine effects. ISRN Ophthalmol. 2011, doi: 10.5402/2011/465198.

Tomlinson A, Bron A.J., Korb D.R., Shiro Amano,Jerry R. Paugh, Yee IPR, Norihiko Yokoi, Arita, R., Dogru M. 2011. The International Workshop on Meibomian Gland Dysfunction: Report of the Diagnosis Subcommittee; Invest Ophthalmol Vis Sci. 52(4), 2006-2049.

Wise R.J., BS, BA; Rachel K. Sobel, Allen R.S., 2012. Meibography A review of techniques and technologies. Saudi Journal of Ophthalmology 26, 349-356




DOI: http://dx.doi.org/10.14748/bro.v0i1.4521

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About The Authors

A. Vassilev
Department of Ophthalmology Medical University-Sofia, Aleksandrovska University Hospital, Sofia
Bulgaria

I. Chernodrinska
Department of Ophthalmology Medical University-Sofia, Aleksandrovska University Hospital, Sofia
Bulgaria

St. Kostova
Department of Ophthalmology Medical University-Sofia, Aleksandrovska University Hospital, Sofia
Bulgaria

M. Slavkova
Department of pharmaceutical technology, Faculty of Pharmacy, Medical University-Sofia
Bulgaria

Y. Zdravkov
Department of Ophthalmology Medical University-Sofia, Aleksandrovska University Hospital, Sofia
Bulgaria

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