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Bulgarian Review of Ophthalmology

Penetrating keratoplasty for the treatment of corneal perforations

S. Murgova, Ch. Balabanov, G. Yordanov


The purpose of this study was to analyze the results obtained after administration of various surgical techniques for the treatment of corneal perforations.

Material and methods: The study included patients with different size and location of corneal perforation.
Various methods of treatment were done - corneal scleral patch, amniotic membrane transplantation, cyanoacrylate glue and keratoplasty.

Results: 25 patients with corneal perforation, for the period 2007-2012, had surgical treatment at Eye clinic Pleven. The patients were divided into four groups according to the surgical procedure - corneo-scleral patch surgery was performed on 8 eyes, cyanoacrylate glue in 4 patients, amniotic membrane transplantation in 4 cornea was restored, except one case where the cause for perforation was chemical burn. In the group of patients with amniotic membrane transplantation in 3 cases corneal defect fully healed, while in one case failed to heal because the size of perforation was 3mm and keratoplasty was performed. Seven patients with keratoplasty had clear graft in late postoperative period, one had hemi transparent and in one case graft was rejected. In all cases the integrity of the cornea was restored and gradually improvement of visual acuity was achieved.

Conclusion: In cases with small perforations preferred method of treatment are amniotic membrane transplantation and cyanoacrylate glue, and for large corneal defect the choice of treatment is keratoplasty.


corneal perforation; keratoplasty; cyanoacrylate glue; amniotic membrane; corneo-scleral patch

Full Text


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About The Authors

S. Murgova
Eye clinic - MU Pleven

Ch. Balabanov
Eye clinic - MU Pleven

G. Yordanov
MMA Sofia, eye clinic