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Bulgarian Review of Ophthalmology

Physiological changes of the visual system during pregnancy

K. Trifonova, G. Jordanov, J. Jordanov, K. Trifonova, K. Slaveykov


Introduction: Visual system goes through several physiological changes during pregnancy that should be recognized because in most cases they are harmless and reversible.

Aims and tasks: To make a literature review of the physiological ocular changes, that can occur during pregnancy.

Methods and materials: Literature review

Results: The most often and definite changes during pregnancy are lowering of intraocular pressure as well worsening of tear ? lm quality. Many changes of the cornea are shown in different studies including decreasing of its sensitivity, increasing of its thickness and curvature. Often the results are contradictory. Changes in refraction are mainly in myopisation and loss of accommodation.

Conclusion: We need to know the effects of pregnancy on vision in order to avoid unnecessary treatment when the changes are physiological. The effects of pregnancy on visual system need to be better investigated and in the context of an existing pathological state they could give us more information about the causes and treatment of some diseases.


pregnancy; effects; visual system

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Akar Y, Yucel I, Akar ME, Zorlu G, Ari ES., Eff ect of pregnancy on intraobserver and intertechnique agreement in intraocular pressure measurements. Ophthalmologica, 2005, 219:36–42

Arya S, Malik A, Gupta S, Gupta H, Sood S., Spontaneous corneal melting in pregnancy: a case report, J Med Case Rep., 2007, 1:143

Ataş M, Duru N, Ulusoy D et al, Evaluation of anterior segment parameters during and aft er pregnancy, Cont Lens Anterior Eye., 2014, 37(6):447-50

Bilgihan K, Hondur A, Sul S, Ozturk S., Pregnancy-induced progression of keratoconus. Cornea., 2011, 30(9):991-4

Cankaya C, Bozkurt M, Ulutas O., Total macular volume and foveal retinal thickness alterations in healthy pregnant women, Semin Ophthalmol, 2013, 28(2):103-11

Chan C-C, Reed GF, Kim Y, Agrón E, Buggage RR. A correlation of pregnancy term, disease activity, serum female hormones, and cytokines in uveitis. British Journal of Ophthalmology, 2004, 88(12):1506 1509

Chiam N, Hall A, Stawell R, Busija L, Lim LL., The course of uveitis in pregnancy and postpartum, Br J Ophthalmol, 2013, 97(10):1284-8

Chiam N, Lim LL.,Uveitis and gender: the course of uveitis in pregnancy. J Ophthalmol. 2014;2014:401915. doi: 10.1155/2014/401915. Epub 2014

Ding C, Lu M, Huang J., Changes of the ocular surface and aquaporins in the lacrimal glands of rabbits during pregnancy, 2011, 17:2847- 55

Ebeigbe J, Ebeigbe P, Ighoroje A., Intraocular pressure in pregnant and non-pregnant Nigerian women, Afr J Reprod Health, 2011, 15(4):20-3)

Efe Y, Ugurbas S, Alpay A, Ugurbas S., Th e course of corneal and intraocular pressure changes during pregnancy., Can J Ophthalmol, 2012 Apr;47(2):150-4

Goktas S, Basaran A, Sakarya Y, et al, Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography, Arq Bras Oft almol, 2014, 77(3):148-51

Goldich Y, Cooper M, Barkana Y, Ocular anterior segment changes in pregnancy, J Cataract Refract Surg, 2014, 40(11):1868-71

Gotovac M, Kastelan S, Lukenda A., Eye and pregnancy, Coll Antropol, 2013, Suppl 1:189- 93

Hafezi F, Iseli HP., Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking, J Cataract Refract Surg, 2008 Jul;34(7):1219-21

Hoogewoud F, Gatzioufas Z, Hafezi F., Transitory topographical variations in keratoconus during pregnancy, J Refract Surg, 2013, 29(2):144-6

Kara N, Sayin N, Pirhan D et al, Evaluation of subfoveal choroidal thickness in pregnant women using enhanced depth imaging optical coherence tomography, Curr Eye Res., 2014, 39(6):642-4

Kubicka-Trzaska A, [Endogenous uveitis during pregnancy--a report of 4 cases], Klin Oczna, 2004, 106(3):328-31

Kump L, Cervantes-Castañeda R, Androudi S, Foster C, Christen W, Patterns of exacerbations of chronic non-infectious uveitis in pregnancy and puerperium, Ocul Immunol Infl amm, 2006, 14:99-104

Lahoud S, Brownstein S, Lafl amme MY, Poleski SA., Keratoconus with spontaneous perforation of the cornea, Can J Ophthalmol, 1987, 22(4):230-3

López-Prats MJ1, Hidalgo-Mora JJ, Sanz- Marco E et al, [Infl uence of pregnancy on refractive parameters aft er LASIK surgery], Arch Soc Esp Oftalmol. 2012, 87(6):173-8

Milodot M, British journal of Ophthalmology, The influence of pregnancy on the sensitivity of the cornea, 1977, 61, 646-649

Oh J, Kim M, Park J, Wee W., Spontaneous corneal melting during pregnancy: a case report, Cases J, 2009, 10.1186/1757-1626-2-7444

Padmanabhan P, Radhakrishnan A, Natarajan R., Pregnancy-triggered iatrogenic (post-laser in situ keratomileusis) corneal ectasia-a case report, Cornea, 2010, 29(5):569-72

Park S, Lindahl K, Temnycky G, Aquavella J, Th e eff ect of pregnancy on corneal curvature, CLAOJ, 1992, 18: 256-9

Pilas-Pomykalska M, Czajkowskii J, Oszukowski P., Ocular changes during pregnancy, Ginekol Pol, 2005, 76: 655-60

Pilas-Pomykalska M1, Luczak M, Czajkowski J et al, [Changes in intraocular pressure during pregnancy], Klin Oczna, 2004, 106(1-2 Suppl):238-9

Pizzarello L, Refractive changes in pregnancy, Graefes Arch Clin Exp Ophthalmol, 2003, 241(6):484-8

Rabiah P, Vitale A., Noninfectious uveitis and pregnancy, Am J Ophthalmol, 2003, 136(1):91-8

Riss B, Riss P., Corneal sensitivity in pregnancy, Ophthalmologica, 1981,183: 57- 62

Samuel C, Coghlan J, Bateman J., Effects of relaxin, pregnancy and parturition on collagen metabolism in rat pubic symphysis, Journal of Endocrinology, 1998, 159:117-2

Saylik M, Saylık S., Not only pregnancy but also the number of fetuses in the uterus aff ects intraocular pressure, Indian J Ophthalmol, 2014, 62(6):680-2

Schechter J, Carey J, Wallace M, Wood R., Distribution of growth factors and immune cells are altered in the lacrimal gland during pregnancy and lactation. Exp Eye Res, 2000, 71(2):129-42

Schechter J, Pidgeon M, Chang D et al, Potential role of disrupted lacrimal acinar cells in dry eye during pregnancy, 2002, 506(Pt A):153-7

Skare T, Gehlen M, Silveira D, Uema M., Lacrimal dysfunction and pregnancy, Rev Bras Ginecol Obstet, 2012, 34(4):170-4

Spoerl E, Zubaty V, Raiskup-Wolf F, Pillunat LE, Oestrogen-induced changes in biomechanics in the cornea as a possible reason for keratectasia, Br J Ophthalmol, 2007, 91:1547-1550

Suzuki T, Sullivan DA., Estrogen stimulation of proinflammatory cytokine and matrix metalloproteinase gene expression in human corneal epithelial cells, Cornea, 2005, 24:1004-1009

Taguchi C, Ikeda E, Hikita N, Mochizuki M., A report of two cases suggesting positive influence of pregnancy on uveitis activity, Nihon Ganka Gakkai Zasshi, 1999, 103:66-71

Takahashi J, Kado M, Mizumoto K, Igarashi S, Kojo T., Choroidal thickness in pregnant women measured by enhanced depth imaging optical coherence tomography, Jpn J Ophthalmol, 2013, 57(5):435-9

Ulusoy D, Duru N, AtaÅŸ M et al, Measurement of choroidal thickness and macular thickness during and aft er pregnancy, Int J Ophthalmol, 2015, 8(2):321-5

Vora R, Gupta R, Mehta MJ et al, Pregnancy and skin. J Family Med Prim Care., 2014; 3(4):318-24

Weinreb RN, Lu A, Beeson C. Maternal corneal thickness during pregnancy, Am J Ophthalmol,1988, 105:258-60



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About The Authors

K. Trifonova
Trakia University, Medical Faculty, Stara Zagora, Department of Ophthalmology and general medicine

G. Jordanov
Trakia University, Medical Faculty, Stara Zagora, Department of Ophthalmology and general medicine

J. Jordanov
Trakia University, Medical Faculty, Stara Zagora, Department of Ophthalmology and general medicine

K. Trifonova
Trakia University, Medical Faculty, Stara Zagora, Department of Physiology and Pathophysiology

K. Slaveykov
Trakia University, Medical Faculty, Stara Zagora, Department of Ophthalmology and general medicine