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Bulgarian Review of Ophthalmology

Pattern electroretinography as an objective method for study the visual analyzer function in patients with diabetes mellitus with initial diabetic retinopathy

E. Mermeklieva, G. Grozeva, M. Tomova, D. Solakov, L. Haralanov, V. Damianov


Aim: The aim of the study was to examine objectively the visual analyzer function by pattern electroretinography (PERG) in patients with diabetes mellitus (DM) with initial diabetic retinopathy (DR) and to compare the results with the control group as well as according to the type of diabetes. Material and methods: A group of 81 people (162 eyes) were studied. Patients with DM were 34 (68 eyes), 11 patients with type 1 DM and 23 with type 2 DM. The control group consisted of 47 healthy individuals (94 eyes). PERG was performed. The main variables that were considered in the results analysis were the latency and amplitudes, reflecting the configuration of the wave forms.

Results: The comparative analysis of PERG components between patients with DM with DR and controls as well as according to the type of DM demonstrated significant differences. In latencies, significant differences were found for component P50 at all electrode positions at 15o and 30o. Patients with DM had significantly longer latencies and lower amplitudes compared to the control group. In the comparative analysis according to the type of DM, significant differences were found in amplitude component P50-N95 at 15o and 30o in the right eye, which confirms the asymmetrical eye involvement in DM. The PERG amplitudes in type 2 DM were significantly lower than those of type 1 DM patients.

Conclusion: PERG could be used as an objective method for registration of early changes in the visual analyzer function as a DM complication. Also, to monitor the changes in dynamics as it is non-invasive, harmless, faster, and less expensive than fluorescein angiography (FA), OCT and angio-OCT.


pattern electroretinography; diabetes mellitus; diabetic retinopathy

Full Text


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About The Authors

E. Mermeklieva
Clinic of Ophthalmology, University Hospital "Aleksandrovska", Sofia, Bulgaria

G. Grozeva
Clinical center of endocrinology and gerontology, Medical University - Sofia, Bulgaria

M. Tomova
Clinical center of endocrinology and gerontology, Medical University - Sofia, Bulgaria

D. Solakov
Clinic of Neurology, NHH, Bulgaria

L. Haralanov
Clinic of Neurology, NHH, Bulgaria

V. Damianov
DCC 8, Sofia, Bulgaria