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Bulgarian Review of Ophthalmology

Non-Infectious Uveitis in Childhood – Preliminary Results

M. Markova, S. Stefanov, A. Telcharova, A. Oskar


The purpose of the present study was to extend our knowledge of the occurrence, characteristics, severity and prognosis of uveitis in children with juvenile idiopathic arthritis (JIA). A total of 31 children with autoimmune diseases (usually associated with noninfectious uveitis) or isolated noninfectious uveitis were studied. The most of the cases are children with JIA. The major group of the children with JIA has oligoarthritis (four or less joints are affected). Uveitis was chronic (duration >6 months), the most severe cases being those three, in whom uveitis was detected at the onset of arthritis – 3 children. The most important determinants of associated uveitis are early onset of arthritis (at the age of 2 to 4 years) and antinuclear antibody (ANA) positivity. The condition in most cases was found early in the disease process, in a majority of cases during the first four years from the onset of arthritis. Proportionally uveitis was more frequent in rheumatoid factor-seronegative polyarthritis and oligoarthritis and there is predominance of girls (2.3:1 – girls:boys). There are complications (band keratopathy, cataract, secondary glaucoma) in 25.8% of cases. Clinical remission of arthritis was achieved significantly less frequently in patients with uveitis than in those without. In some patients the treatment of chronic uveitis associated with JIA is difficult, and in such cases the collaboration of ophthalmologists and pediatric rheumatologist is essential in determining the optimal management early in the disease course.


noninfectious uveitis, children, complications, treatment

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Patterns of uveitis in children according to age: comparison of visual outcomes and complications in a tertiary center. BMC Ophthalmol. 2019; 19:137. Published online 2019 Jun 27. doi: 10.1186/s12886-019-1139-5.

Morelle G, Gueudry J, Uettwiller F et al. Chronic and recurrent non-infectious paediatric-onset uveitis: a French cohort. RMD Open, 2019 Aug 5;5(2):e000933. doi: 10.1136/rmdopen-2019-000933.

Siiskonen M, Hirn I, Pesälä R et al. Prevalence, incidence and epidemiology of childhood uveitis. Acta Ophthalmol, 2021 Mar;99(2):e160-e163.

Pakzad-Vaezi K, Pepple KL. Tubulointerstitial nephritis and uveitis. Curr Opin Ophthalmol, 2017 Nov;28(6):629-635. doi: 10.1097/ICU.0000000000000421.

Clinical Presentation, Management and Long Term Outcome of Pars Planitis (PP), Panuveitis (PU) and Vogt-Koyanagi-Harada disease (VKH) in Children and Adolescents. Arthritis Care Res (Hoboken), 2019 Aug 23. doi: 10.1002/acr.24056.

Albaroudi N, Tijani M, Boutimzine Net al. Clinical and therapeutic features of pediatric Vogt-Koyanagi-Harada disease. J Fr Ophtalmol, 2020 May;43(5):427-432. Doi: 10.1016/j.jfo.2019.10.005.

Pinheiro Kahwage P, Paes Leme Ferriani M, Furtado JM. Uveitis in childhood-onset systemic lupus erythematosus patients: a multicenter survey. Clin Rheumatol, 2017 Mar;36(3):547-553. doi:10.1007/s10067-016-3534-0.

Tugal-Tutkun I. Pediatric Uveitis. J Ophthalmic Vis Res, 2011 Oct; 6(4): 259-269.

Treudler R, Orfanos CE, Zouboulis CC. Twenty-eight cases of juvenile-onset Adamantia-des-Behcet disease in Germany. Dermatology,1999;199:1509.

Eiger-Moscovich M, Tomkins-Netzer O, Amer R et al. Visual and Clinical Outcome of Macular Edema Complicating Pediatric Noninfectious Uveitis. Am J Ophthalmol, 2019 Jun;202:72-78. doi: 10.1016.

Ducos de Lahitte G, Terrada C, Tran THC. Maculopathy in uveitis of juvenile idiopathic arthritis: an optical coherence tomography study. Br J Ophthalmol, 2008 Jan;92(1):64-9. doi: 10.1136/bjo.2007.120675.

Maccora I, Sen ES, Ramanan AV. Update on noninfectious uveitis in children and its treatment. Curr Opin Rheumatol, 2020 Sep;32(5):395-402.



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About The Authors

M. Markova
Medical University – Sofia

Chair of Ophthalmology

S. Stefanov
SHATCD “Prof. Iv. Mitev” – Sofia

Clinic of Cardiology and Rheumatology

A. Telcharova
SHATCD “Prof. Iv. Mitev” – Sofia

Clinic of Cardiology and Rheumatology

A. Oskar
Medical University – Sofia

Chair of Ophthalmolgy

Clinic of Eye Diseases, UMHAT “Aleksandrovska” – Sofia