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Bulgarian Review of Ophthalmology

Ophthalmic Status of Newborn Children at Risk – Preliminary Results

G. Tsvetkova, A. Oscar

Abstract

Retinopathy of prematurity (ROP) is a leading cause of low vision and preventable blindness among the pediatric population with gestational age, birth weight, stage of retinopathy as well as the need and type of treatment being of crucial significance. Purpose: To present preliminary results of the ophthalmic examination of newborn children at risk (with low and extremely low weight, preterm gestational age at birth), as to follow up the occurrence or absence of changes in the ophthalmic status of those with or without diagnosed ROP. Patients and methods: In the current study are participating 112 eyes of 56 children (24 boys and 32 girls), examined between March 2021 and August 2021 at the Pediatric Ophthalmic Outpatient Care Center and the Pediatric Ophthalmic Department of the University Hospital Aleksandrovska. The complete ophthalmic exam included assessment of: visual acuity, orthoptic status, biomicroscopy, ophthalmoscopy, autorefractometry/skiascopy, optical coherence tomography. Results: The patients were divided into two main groups: with and without diagnosed ROP. 19 children (38 eyes) were included in the first group, and 37 children (74 eyes) – in the second. The mean age of the examined children was 66.9 months, the mean gestational age at birth – 28.2 weeks, and the mean weight – 1041.13 g. 11 of the patients with diagnosed ROP were also treated for the condition. 9 of the premature children with diagnosed ROP required prescription of an optical correction. 5 of the children show deviation of the orthoptic status. Optical coherence tomography was conducted in 11 of the children, 10 of whom showed pathological irregularities in the results. Conclusion: Our study confirms the high prevalence of refractive anomalies and deviations of the orthoptic status in patients diagnosed with ROP. The early screening, as well as the introduction and integration of follow-up programs are important for reduction of the organic, functional, social and psycho-emotional consequences of ROP.


Keywords

retinopathy of prematurity, newborn children at risk, ophthalmic status, refraction, late complications

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References

Vijayalakshmi P, Kara T, Gilbert C. Ocular Morbidity Associated With Retinopathy of Prematurity in Treated and Untreated Eyes: A Review of the Literature and Data From a Tertiary Eye-care Center in Southern India. Indian Pediatr, 2016;53 (Suppl 2):S137-S42.

Чернодринска В, Оскар А, Чернинкова С. Ret Cam скрининг на недоносените деца и оценка на рисковите фактори за развитие на ретинопатия. Педиатрия, 2012, (4): 21-23.

Tin W, Miligan DWA, Pennefather P et al. Pulse oximetry, severe retinopathy, and outcome at one year in babies of less than 28 weeks gestation. Arch Dis Child Fetal Neonatal Ed, 2001, 84, F106-F110.

Shah PK, Prabhu V, Karandikar SS et al. Retinopathy of prematurity: Past, present and future. World J Clin Pediatr, 2016;5(1):35-46.

Blencowe H, Cousens S, Chou D et al. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health, 2013;10 Suppl 1:S2.

Lad EM, Nguyen TC, Morton JM et al. Retinopathy of prematurity in the United States. Br J Ophthalmol, 2008;92(3):320-5.

Mladenov O. Dynamics of Retinal Changes in Premature Babies. PhD work, Sofia. 2016

Good WV. Early Treatment for Retinopathy of Prematurity Cooperative G. Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial. Trans Am Ophthalmol Soc, 2004;102:233-48; discussion 48-50.

Kaiser RS, Trese MT, Williams GA et al. Adult retinopathy of prematurity: outcomes of rhegmatogenous retinal detachments and retinal tears. Ophthalmology, 2001;108(9):1647-53.

Mintz-Hittner HA, Kennedy KA, Chuang AZ. Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med, 2011;364(7):603-615.

Marinov V, Sivkova N, Krasteva M et al. Visual and refractive outcome after 7 years of treatment of type 1 prethreshold ROP in Plovdiv region. SOE. Barcelona, Spain, 2017. Abstract book. 2017.

Cryotherapy for Retinopathy of Prematurity Cooperative Group. Multicentre trial of cryotherapy for retinopathy of prematurity. 3.5 year outcome-structure and function. Arch Ophthalmol, 1993;111:339-44.https://doi.org/10.1001/archopht.1993.01090030057039.

Nguyen PH, Catt C, Nguyen TX et al. Refractive outcome of prethreshold retinopathy of prematurity treated by diode laser:follow-up at 5 years. Clin Ophthalmol, 2015;9:1753-1758.

Lolas M, Tuma A, Zanolli M et al. Anatomical and refractive outcomes in patients with treated retinopathy of prematurity. Arch Soc Esp Oftalmol, 2017;92(10):472-476.

Veleva N, Chernodrinska V. Refractive Status in Children with Laser-Treated Retinopathy of Prematurity: Our Experience in Bulgaria. Open Access Maced J Med Sci, 2019 Apr 30; 7(8): 1320-1323.

Young-ZvandasaraT, Popiela M, Preston H. Is the severity of refractive error dependent on the quantity and extent of retinal laser ablation for retinopathy of prematurity? Eye (Lond), 2020 Apr;34(4):740-745.

Kong Q, Ming W-K, Mi X-S. Refractive outcomes after intravitreal injection of antivascular endothelial growth factor versus laser photocoagulation for retinopathy of prematurity: a metaanalysis. BMJ Open, 2021,11(2): e042384.

Jeon SH, Roh Y-J. Ten-year outcomes after initial management with laser photocoagulation versus intravitreal bevacizumab injection in a pair of identical twins with aggressive posterior retinopathy of prematurity. Am J Ophthalmol Case Rep, 2021 May 2; 22:101097.

Geloneck MM, Chuang AZ, Clark WL et al. Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment:a randomized clinical trial. JAMA Ophthalmol, 2014;132:1327-33. https://doi.org/10.1001/jamaophthalmol.2014.2772 PMid:25103848.

Kuo HK, Sun IT, Chung MY et al. Refractive error in patients with retinopathy of prematurity after laser photocoagulation or Bevacizumab Monotherapy. Ophthalmologica, 2015;234:211-217.

Оскар А, Чернодринска В, Петкова И. Клиничен случай на дете с ретинопатия на недоносеността лекувано с интравитреална апликация на Bevacizumab (Avastin). Педиатрия, 2012, (1):52-53.

Ecsedy M, Szamosi A, Karko C et al. A comparison of macular structure imaged by optical coherence tomography in preterm and full-term children. Invest Ophthalmol Vis Sci, 2007;48:5207-5211.

Lee Y-S, Chang SHL, Wu S-C et al. The inner retinal structures of the eyes of children with a history of retinopathy of prematurity. Eye (Lond), 2018 Jan;32(1):104-112.




DOI: http://dx.doi.org/10.14748/bro.v66i1.8378

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About The Authors

G. Tsvetkova
Medical University ‒ Sofia
Bulgaria

Department of Ophthalmology

University Clinic of Eye Diseases, University Hospital Aleksandrovska ‒ Sofia

A. Oscar
Medical University ‒ Sofia
Bulgaria

Department of Ophthalmology

University Clinic of Eye Diseases, University Hospital Aleksandrovska ‒ Sofia

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