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Treatment Of Infantile Hepatic Hemangiomas With Propranolol – A Clinical Case

Petar Shivachev, Miglena Georgieva, Kalina Ganeva


Infantile hepatic hemangiomas are the most common benign tumors of the liver in childhood, which can sometimes lead to life-threatening complications and death. The therapeutic approach is different and includes: surveillance, interventional, surgical or drug treatment. In recent years, the drug of choice is propranolol. 

We present a clinical case of a two-month-old infant with multiple infantile cutaneous hemangiomas. An enlarged liver with multifocal hepatic hemangiomas was detected by ultrasound and computed tomography. No evidence of high cardiac output or heart failure was observed. The alpha-fetoprotein and thyroid-stimulating hormone levels were initially elevated. Propranolol solution was administered in weekly doses up to 3 mg/mg, twice daily. As early as the second month of starting treatment, regression of liver lesions was observed by echocardiography.

The present case confirms the positive effect of early treatment with propranolol in infantile hepatic hemangiomas, decreasing the lesions and preventing complications in the progression of the disease.


hepatic hemangiomas, infantile hemangiomas, propranolol

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