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Izvestia Journal of the Union of Scientists - Varna. Medicine and Ecology Series

Alcohol and the cognitive functions of the aging brain

Margarita Stefanova Velikova, Zlatislav Stoyanov Dimitrov

Abstract

Old age is a factor in the onset of degenerative brain diseases among which dementia, associated with severe cognitive impairment. The study analyzes the literature data, accumulated over the years, concerning the impact of moderate alcohol consumption on cognitive processes in the elderly. Recent reports reveal that light-to-moderate consumption of alcohol does not reduce the risk of cognitive decline in old age. Moderate alcohol consumption does not improve cognitive function and is associated with lower cognitive performance in a dose-dependent manner.


Keywords

cognitive function, alcohol consumption, ageing

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References

Almeida, O. P., Hankey, G. J., Yeap, et al. Alcohol consumption and cognitive impairment in older men A mendelian randomization study. Neurology. 2014; 82, 1038–1044.

Anstey, K.J., Mack, H.A., Cherbuin, N., et al. Alcohol consumption as a risk factor fordementia and cognitive decline: meta-analysis of prospective studies. Am. J.Geriatr. Psychiatry. 2009; 17, 542–555.

Belmadani A, Kumar S, Schipma M, et al. Inhibition of amyloid-beta-induced neurotoxicity and apoptosis by moderate ethanol preconditioning. Neuroreport. 2004; 15: 2093–2096.

Chikritzhs, T., Stockwell, T., Naimi, T, et al. Has the leaning tower of presumed health benefits from “moderate” alcohol use finally collapsed? Addiction. 2015; 110, 726–72.

Collins MA, Neafsey EJ, Wang K, et al. Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms. Mol Neurobiol 41: Brain Pathol. 2010; 18:240–252.

Handing EP, Andel R, Kadlecova P, et al. Midlife Alcohol Consumption and Risk of Dementia Over 43 Years of Follow-Up: A Population-Based Study From the Swedish Twin Registry. J Gerontol A Biol Sci Med Sci. 2015; 70(10): 1248-54.

Hassing LB. Light Alcohol Consumption Does Not Protect Cognitive Function: A Longitudinal Prospective Study. Front.Aging Neurosci., 2018; 10:81.

Lichtenstein, P., De Faire, U., Floderus, et al. The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. J. Intern. Med. 2002; 252(3):184-205.

McClearn, G. E., Johansson, B., Berg, S. et al. Substantial genetic influence on cognitive abilities in twins 80 or more years old. Clin. Orthop. Relat. Res. 1997; 276, 1560–1563

Miners JS, Baig S, Palmer J, et al. Abeta-degrading enzymes in Alzheimer’s disease. Brain Pathol. 2008; 18: 240–252.

Oscar-Berman M, Marinkovic K. Alcohol: Effects on neurobehavioral functions and the brain. Neuropsychology Review. 2007;17:239–257.

Panza F, Capurso C, D'Introno A, et al. Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes. J Alzheimers Dis. 2009; 17 (1):7-31.

Panza F, Frisardi V, Seripa D, et al. Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective? Int J Geriatr Psychiatry. 2012; 27(12):1218-38

Peters R, Peters J, Warner J, et al. Alcohol, dementia and cognitive decline in the elderly: a systematic review. Age Ageing. 2008; 37(5):505-12.

Ruitenberg A, van Swieten JC, Witteman JC, et al. Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet. 2002; 359:281–286.

Solfrizzi V, D’Introno A, Colacicco AM, et al. Alcohol consumption, mild cognitive impairment,and progression to dementia. Neurology. 2007; 68:1790–1799.

Stancampiano R, Carta M, Cocco S, et al. Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex. Brain Res. 2004; 997: 128–132.

Stockwell, T., Zhao, J. H., Panwar, et al. Do “moderate” drinkers have reduced mortality risk? A systematic review and meta-analysis of alcohol consumption and all-cause mortality. J. Stud. Alcohol Drugs. 2016; 77, 185–198.

Topiwala A, Allan CL, Valkanova V, et al. Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study BMJ. 2017; 357:j2353.

Wang Q, Sun AY, Simonyi A, et al. Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROS. Free Radic BiolMed. 2007; 43: 1048–1060.

WHO Global status report on alcohol and health 2018" (PDF). who.int.

Willcox BJ, He Q, Chen R, et al. Midlife risk factors and healthy survival in men. JAMA. 2006; 296:2343–2350.




DOI: http://dx.doi.org/10.14748/isuvsme.v24i1.6193

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