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Izvestia Journal of the Union of Scientists - Varna. Medicine and Ecology Series

MicroRNAs and cardiac health. Their role as a potential biomarker for heart dysfunction

Kalina Ganeva

Abstract

MicroRNAs are small non-coding molecules that act as regulators to many physiological and pathological reactions. They have been found to be important for the normal development of the cardiovascular system as well as for many pathological processes such as cardiac hypertrophy, cardiac fibrosis, and remodeling. Their wide distribution in body fluids, stability, and resilience make them particularly suitable for isolation, identification and research. There are many pieces of evidence about the role of certain microRNAs in pathogenesis and progression of cardiac failure (microRNA-1, microRNA-21, microRNA-29, microRNA-150), fibrosis (microRNA-21, microRNA-29) and cardiac remodeling by regulating the expression of target genes. In theory, microRNAs have many of the specificities needed for an ideal biomarker—regulators of many pathological processes, wide distribution in biological fluids, stability, and sustainability. At this stage, data on microRNAs is in the field of research, which is why their use in clinical practice is not yet widespread. However, they stand out as a reliable method with great potential for application, both in diagnosis and in targeted therapy.

Keywords

microRNAs, cardiogenesis, cardiac remodeling, fibrosis

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References

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DOI: http://dx.doi.org/10.14748/isuvsme.v26i1.8081

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