Scientific Online Resource System

Journal of the Union of Scientists - Varna. Medicine and Ecology Series

Uveitis and systemic diseases

Silviya Nikolaeva, Binna Nencheva


Introduction: Uveitis is one of the main causes of eye disease and blindness. Uveitis may be the most common extra-articular manifestation, occurring in 20 to 30% of patients with ankylosing spondylitis.

Aim: The aim of the present study is to analyze the patients with uveitis and systemic diseases treated in Specialized Eye Hospital, Varna in the period 2019–2021.

Materials and Methods: The study included 60 patients with uveitis, analyzing demographic factors, visual acuity, severity of the disease, the presence of recurrences, affected eye, the presence of systemic disease. The results were processed with SPSS v. 20.0, using variance, variation, comparative and correlation analysis, risk assessment analysis. For significance level we assumed p < 0.05.

Results: The average age of patients with uveitis was 52.2 ± 18.2 years (7–84 years), dominated by men (51.7%) and urban residents (88.3%). A total of 21.7% (13) of the studied patients had systemic diseases, of which 61.5% had Bechterew's disease. In 84.5% of the cases there was unilateral involvement with 69.6% being of moderate severity. Recurrences were found in 34.5%. There was a significant difference (p = 0.024) and a moderate relationship between recurrence and systemic disease (r = 0.306; p = 0.02). The presence of systemic disease carried a 4.4-fold higher risk of recurrence (OR = 4.4 (1.201–16.114); p < 0.05).

Conclusion: Approximately one-fifth of the patients with uveitis included in the study had systemic disease, the most common being Bechterew's disease, followed by herpes simplex infection. The combination of uveitis with systemic disease or infection requires an interdisciplinary approach to diagnosis and treatment of the disease.


uveitis, systemic diseases, assessment

Full Text


Agrawal RV, Murthy S, Sangwan V, Biswas J. Current approach in diagnosis and management of anterior uveitis. Indian J Ophthalmol. 2010 Jan-Feb;58(1):11-9

Chang JH, Wakefield D. Uveitis: a global perspective. Ocul Immunol Inflamm. 2002;10:263–279

Chao JR, Khurana RN, Fawzi AA, Reddy HS, Rao NA. Syphilis: reemergence of an old adversary. Ophthalmology. 2006;113:2074–2079

Chatzistefanou K, Markomichelakis NN, Christen W, et al. Characteristics of uveitis presenting for the first time in the elderly. Ophthalmology. 1998;105:347–352

Cimino L, Herbort CP, Aldiferi R, Salvarani C, Boiardi L. Tuberculous uveitis, a resurgent and underdiagnosed disease. Int Ophthalmol. 2009;29:67–74

Crawford CM, Igboeli O. A review of the inflammatory chorioretinopathies: The white dot syndromes. ISRN Inflamm. 2013 Oct 31;2013:783190

de Smet MD, Taylor SR, Bodaghi B, et al. Understanding uveitis: the impact of research on visual outcomes. Prog Retin Eye Res. 2011;30:452–470

El MA. Extra-articular manifestations of ankylosing spondylitis: prevalence, characteristics and therapeutic implications. Eur J Intern Med 2011; 22:554–560

Gasch AT, Smith JA, Whitcup SM. Birdshot retinochoroidopathy. Br J Ophthalmol. 1999;83:241–249

Gouveia EB, Elmann D, Morales MS. Ankylosing spondylitis and uveitis: overview. Rev Bras Reumatol 2012; 52:742–756

Heiligenhaus A, Minden K, Föll D,et al.Uveitisinjuvenile idiopathic arthritis. Dtsch Arztebl Int. 2015;112:92–100

Islam SM, Tabbara KF. Causes of uveitis at The eye center in Saudi Arabia: a retrospective review. Ophthalmic Epidemiol. 2002;9:239–249

Kotake S, Furudate N, Sasamoto Y, et al. Characteristics of endogenous uveitis in Hokkaido, Japan. Graefes Arch Clin Exp Ophthalmol. 1997;235:5–9

Muñoz-Fernández S, Martín-Mola E. Uveitis. Best Pract Res Clin Rheumatol. 2006;20:487–505

Nalcacioglu-Yuksekkaya P, Ozdal PC, Yazici A, et al. Clinical and demographic characteristics of patients with uveitis starting later in life. Ocul Immunol Inflamm. 2015;23:304–310

Oruc S, Kaplan AD, Galen M, et al. Uveitis referral pattern in a Midwest University Eye Center. Ocul Immunol Inflamm. 2003;11:287–298

Rathinam SR, Namperumalsamy P. Global variation and pattern changes in epidemiology of uveitis. Indian J Ophthalmol. 2007;55:173–183

Rothova A, Buitenhuis HJ, Meenken C, et al. Uveitis and systemic disease. Br J Ophthalmol. 1992;76:137–141

Saari KM, Päivönsalo-Hietanen T, Vaahtoranta-Lehtonen H, et al. Epidemiology of endogenous uveitis in southwestern Finland. Acta Ophthalmol Scand. 1995;73:345–349

Sharma SM, Jackson D. Uveitis and spondyloarthropathies. Best Pract Res Clin Rheumatol. 2017 Dec;31(6):846–862

Smit RL, Baarsma GS, de Vries J. Classification of 750 consecutive uveitis patients in the Rotterdam Eye Hospital. Int Ophthalmol. 1993;17:71–76

Soheilian M, Heidari K, Yazdani S, et al. Patterns of uveitis in a tertiary eye care center in Iran. Ocul Immunol Inflamm. 2004;12:297–310

Sun L, Wu R, Xue Q, et al. Risk factors of uveitis in ankylosing spondylitis: An observational study. Medicine (Baltimore). 2016 Jul;95(28):e4233

Trusko B, Thorne J, Jabs D, et al. Standardization of Uveitis Nomenclature (SUN) Project. The Standardization of Uveitis Nomenclature (SUN) Project. Development of a clinical evidence base utilizing informatics tools and techniques. Methods Inf Med. 2013;52:259–265, S1–S6

Venkatesh P, Gogia V, Shah B, Gupta S, Sagar P, Garg S. Patterns of uveitis at the apex Institute for eye care in India: Results from a prospectively enrolled patient data base (2011-2013). Int Ophthalmol 2015 Sep 25. (Epub ahead of print)

Wakefield D, Chang JH. Epidemiology of Uveitis. Int Ophthalmol Clin. 2005;45:1–13

Zulian F, Martini G, Falcini F, et al. Early predictors of severe course of uveitis in oligoarticular juvenile idiopathic arthritis. J Rheumatol. 2002;29(11):2446–2453



Font Size