Scientific Online Resource System

Izvestia Journal of the Union of Scientists - Varna. Medicine and Ecology Series

Epicardial fat as an imaging biomarker in the assessment of cardiometabolic risk in patients with type 1 diabetes with a duration of over 15 years

Samar El Shemeri, Daniela Kaloyanova, Georgi Valchev, Kaloyan Tsochev, Tatyana Chalakova, Nataliya Usheva, Yana Bocheva, Violeta Iotova

Abstract

Diabetes mellitus is one of the most frequent metabolic diseases and is characterized by increased coronary risk. Data from epicardial fat quantification in long-term type 1 diabetes patients with poor control and healthy volunteers, performed with computed tomography and magnetic resonance tomography, is analyzed in relation to biochemical and anthropometric indicators. Statistically significant correlations are established between epicardial fat volume and body mass index in diabetic men, as well as between epicardial fat volume and dyslipidemic markers.


Keywords

type 1 diabetes mellitus, coronary risk, dyslipidemia, epicardial fat, obesity

Full Text


References

Ansaldo AM, Montecucco F, Sahebkar A, Dallegri F, Carbone F. Epicardial adipose tissue and cardiovascular diseases. Int J Cardiol. 2019 Mar 1;278:254-260. doi: 10.1016/j.ijcard.2018.09.089. Epub 2018 Oct 1. PMID: 30297191.

Chalakova Т, Yotov Y, Tsochev K, Bocheva Y, Iotova V, Usheva N, Galcheva S, Valchev G. Risk Of Cardiovascular Diseases In People With Type 1 Diabetes Mellitus, Journal of Hypertension: April 2021 - Volume 39 - Issue - p e177-e178 doi: 10.1097/01.hjh.0000746392.58396.1b

Christensen RH, von Scholten BJ, Lehrskov LL, Rossing P, Jørgensen PG. Epicardial adipose tissue: an emerging biomarker of cardiovascular complications in type 2 diabetes? Ther Adv Endocrinol Metab. 2020 May 25;11:2042018820928824. doi: 10.1177/2042018820928824. PMID: 32518616; PMCID: PMC7252363.

Commandeur F, Goeller M, Betancur J, Cadet S, Doris M, Chen X, Berman DS, Slomka PJ, Tamarappoo BK, Dey D. Deep Learning for Quantification of Epicardial and Thoracic Adipose Tissue From Non-Contrast CT. IEEE Trans Med Imaging. 2018 Aug;37(8):1835-1846. doi: 10.1109/TMI.2018.2804799. Epub 2018 Feb 9. PMID: 29994362; PMCID: PMC6076348.

Dönmez Y, Bulut A. Epicardial fat thickness is significantly increased and related to LDL cholesterol level in patients with familial hypercholesterolemia. J Ultrasound. 2019 Sep;22(3):309-314. doi: 10.1007/s40477-019-00368-3. Epub 2019 Mar 9. PMID: 30852775; PMCID: PMC6704218.

Fox CS, Sullivan L, D'Agostino RB Sr, Wilson PW; Framingham Heart Study. The significant effect of diabetes duration on coronary heart disease mortality: the Framingham Heart Study. Diabetes Care. 2004 Mar;27(3):704-8. doi: 10.2337/diacare.27.3.704. PMID: 14988289.

Greif M, Becker A, von Ziegler F, Lebherz C, Lehrke M, Broedl UC, Tittus J, Parhofer K, Becker C, Reiser M, Knez A, Leber AW. Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 May;29(5):781-6. doi: 10.1161/ATVBAHA.108.180653. Epub 2009 Feb 19. PMID: 19229071.

Guglielmo M, Lin A, Dey D, Baggiano A, Fusini L, Muscogiuri G, Pontone G. Epicardial fat and coronary artery disease: Role of cardiac imaging. Atherosclerosis. 2021 Mar;321:30-38. doi: 10.1016/j.atherosclerosis.2021.02.008. Epub 2021 Feb 16. PMID: 33636676.

Hell MM, Achenbach S, Schuhbaeck A, Klinghammer L, May MS, Marwan M. CT-based analysis of pericoronary adipose tissue density: Relation to cardiovascular risk factors and epicardial adipose tissue volume. J Cardiovasc Comput Tomogr. 2016 Jan-Feb;10(1):52-60. doi: 10.1016/j.jcct.2015.07.011. Epub 2015 Jul 29. PMID: 26256553.

Kim SJ, Kim HS, Jung JW, Kim NS, Noh CI, Hong YM. Correlation between epicardial fat thickness by echocardiography and other parameters in obese adolescents. Korean Circ J. 2012 Jul;42(7):471-8. doi: 10.4070/kcj.2012.42.7.471. Epub 2012 Jul 26. PMID: 22870081; PMCID: PMC3409396.

Mandviwala T, Khalid U, Deswal A. Obesity and Cardiovascular Disease: a Risk Factor or a Risk Marker? Curr Atheroscler Rep. 2016 May;18(5):21. doi: 10.1007/s11883-016-0575-4. PMID: 26973130.

Manno C, Campobasso N, Nardecchia A, Triggiani V, Zupo R, Gesualdo L, Silvestris F, De Pergola G. Relationship of para- and perirenal fat and epicardial fat with metabolic parameters in overweight and obese subjects. Eat Weight Disord. 2019 Feb;24(1):67-72. doi: 10.1007/s40519-018-0532-z. Epub 2018 Jun 28. PMID: 29956099.

Mohammadzadeh M, Mohammadzadeh V, Shakiba M, Motevalli M, Abedini A, Kadivar S, Entezari P, Mohammadzadeh A. Assessing the Relation of Epicardial Fat Thickness and Volume, Quantified by 256-Slice Computed Tomography Scan, With Coronary Artery Disease and Cardiovascular Risk Factors. Arch Iran Med. 2018 Mar 1;21(3):95-100. PMID: 29688734.

Muzurović EM, Vujošević S, Mikhailidis DP. Can We Decrease Epicardial and Pericardial Fat in Patients With Diabetes? J Cardiovasc Pharmacol Ther. 2021 Sep;26(5):415-436. doi: 10.1177/10742484211006997. Epub 2021 Apr 12. PMID: 33844605.

Noyes AM, Dua K, Devadoss R, Chhabra L. Cardiac adipose tissue and its relationship to diabetes mellitus and cardiovascular disease. World J Diabetes. 2014 Dec 15;5(6):868-76. doi: 10.4239/wjd.v5.i6.868. PMID: 25512789; PMCID: PMC4265873.

Russo R, Di Iorio B, Di Lullo L, Russo D. Epicardial adipose tissue: new parameter for cardiovascular risk assessment in high risk populations. J Nephrol. 2018 Dec;31(6):847-853. doi: 10.1007/s40620-018-0491-5. Epub 2018 Apr 27. PMID: 29704210.

Villasante Fricke AC, Iacobellis G. Epicardial Adipose Tissue: Clinical Biomarker of Cardio-Metabolic Risk. Int J Mol Sci. 2019 Nov 28;20(23):5989. doi: 10.3390/ijms20235989. PMID: 31795098; PMCID: PMC6929015.

Wang CP, Hsu HL, Hung WC, Yu TH, Chen YH, Chiu CA, Lu LF, Chung FM, Shin SJ, Lee YJ. Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis. Clin Endocrinol (Oxf). 2009 Jun;70(6):876-82. doi: 10.1111/j.1365-2265.2008.03411.x. Epub 2008 Sep 5. PMID: 18778397.

Xu Y, Cheng X, Hong K, Huang C, Wan L. How to interpret epicardial adipose tissue as a cause of coronary artery disease: a meta-analysis. Coron Artery Dis. 2012 Jun;23(4):227-33. doi: 10.1097/MCA.0b013e328351ab2c. PMID: 22361934.

Zhou J, Chen Y, Zhang Y, Wang H, Tan Y, Liu Y, Huang L, Zhang H, Ma Y, Cong H. Epicardial Fat Volume Improves the Prediction of Obstructive Coronary Artery Disease Above Traditional Risk Factors and Coronary Calcium Score. Circ Cardiovasc Imaging. 2019 Jan;12(1):e008002. doi: 10.1161/CIRCIMAGING.118.008002. PMID: 30642215.




DOI: http://dx.doi.org/10.14748/isuvsme.v26i1.8118

Refbacks

Font Size


|