The world is striving for One Health (OH)—the integrated health of humans, animals, plants, and the environment. However, in Bulgaria, this idea is still not well known. The aim of this report is quadripartite: 1) a brief historical presentation of OH; 2) tracking the development of the concept in the Bulgarian context; 3) the introduction of the OH idea into the wider public health research context, including health policies, humanitarian approaches, infection prevention and control, integrative approaches to antimicrobial resistance (AMR); 4) formulation of research strategies within the national project "One Health—Integrative Research and Scientometric Approaches for a Better Quality of Life", launched in 2022. Materials and Methods: Applied mixed-method design, investigating the OH approaches according to the expertise and established strategies for academic development of the investigators of the research team. The application of sociological methods is planned—direct individual anonymous survey and semi-structured interviews with experts in the field of human and veterinary medicine. The horizon scanning technique was applied to study the Bulgarian context. The formulation of the research strategies was done through an adapted version of the nominal group technique. Statistical data processing and analysis will be performed with IBM SPSS v. 25. The study was approved by the Research Ethics Committee of the Medical University of Varna. This text presents the first steps of the scientific project.
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