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Journal of Varna Medical College

Primary large joint endroprosthesis in Paget's disease. Clinical experience

Nikolay Kolarov


Paget’s disease is an idiopathic condition of abnormal bone remodeling in which normal bone is replaced by an active interaction between excessive bone resorption and abnormal new bone formation. The condition is always observed in patients over 40 years of age with asymptomatic lesions discovered incidentally on radiographs. The diagnosis is made with radiographs showing characteristic findings of lesions with a diffuse blastic appearance and laboratory tests showing elevated serum ALP and increased urinary collagen cross-links. Treatment in asymptomatic patients is observation. Medical treatment with bisphosphonates is indicated in symptomatic patients.


primary endoprosthesis, Paget's disease

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