Цел: Да се направи преглед на литературата, относно ефективността на физиологичните разтвори за носни промивки в лечението на синоназалните болести. Оценката се базира на попълване на въпросници.
Източници на данни: Клинични проучвания публикувани в Medline, Cochrane library и EPOS 2012.
Резултати: Носните промивки се използват често като моно или комбинирана терапия при лечението на синоназалните болести, включително алергичния ринит и хроничния риносинуит. Те водят до намаляване на възпалението и облекчаване на назалните симптоми. Определянето на оптимална техника на приложение на солевите разтвори е затруднена, поради факта, че отделните проучвания използват различни устройства за апликация на разтвора, които демонстрират различни ефекти върху мукоцилиарния клирънс и този на възпалителните медиатори.
Заключение: Като цяло, данните показват клинична полза от носните промивки. Последните се понасят добре и имат минимални странични ефекти. Допълнителни изследвания са необходими, за оптимизиране на ефикасността.
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Objective: This review examines the literature regarding nasal saline irrigation in the management ofsinonasal disease. We explore the various properties of nasal irrigation solutions and their effects on nasal symptoms.
Data Sources: English-language studies identified from MEDLINE, ЕPOS (2012) and the Cochrane Central Register of Controlled Trials.
Study Selections: Randomized, controlled trials (RCTs), prospective controlled and comparative studies, and observational studies reporting on the indications, efficacy, and safety of nasal saline irrigation.
Results: Nasal saline irrigation has often been used as both a solo and an adjunctive treatment in sinonasal diseases, including allergic rhinitis and chronic rhinosinusitis. Nasal saline irrigation has contributed to a reduction of inflammation as well as relief of nasal symptoms. Identifying the optimal technique is hampered by the fact that studies have employed
various delivery devices and saline compositions, which subsequently have demonstrated different effects on mucus clearance, ciliary beat activity, and inflammatory mediators.
Conclusion: Overall, the data appear to demonstrate clinical benefit to nasal saline irrigation. Nasal saline irrigation is well tolerated, with side effects. Further definitive studies are needed to optimize efficacy.
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EPOS 2012
