lntrodustion: Primary lymphoma of the lacrimal drainage system (LDS) presents an extremely rare condition.
Case report: We represent a clinical case of a 70-year old female patient, which preseneted at the Department of oto-rhinolaryngology with complains of a mass over right median eye angle with local pain and epiphora since approximately 3 months. Head CT scan revealed solid tumoral mass. Surgical resection was performed. The specimen was stained with H&E and an immunohistochemical panel with antibodies directed against CD3 and CD20 was applied. B-ccll non-Hodgkin's lymphoma (NHL) was diagnosed. The patient was staged as stage IV HNL.
Conclusion: Primary involvement of LDS by NHL is extremely rare. The most cases described in the literature are of the B-ccll type, the T-cell type being extreme rareness. As only of patients with LDS involvement the incidence of NHL is estimated at 1/2000.
Bolzoni A, Pianta L, Farina D, Nicolai P. Benign myoepithelioma of the lacrimal gland: report of a case Eur Arch Otorhinolaryngol 2005; 262: 186-188
Devesa PM. Spontaneous orbital haematoma The Journal of Laryngology and Otology 2002; 116: 960-961
Gao HW, Lee HS, Lin YS, Sheu LF. Primary lymphoma of nasolacrimal drainage system: a case report and literature review. Am J Otolaryngol 2005; 26: 356-359
Merkonidis C, Brewis C, Yung M, Nussbaumer M. Is routine biopsy of the lacrimal sac wall indicated at dacryocystorhinostomy? A prospective study and literature review Br J Ophthalmol 2005; 89: 1589-1591
Sjo LD, Ralfkiaer E, Juhl BR, Prause JU, Kivelii T, Auw-Haedrich C, Bacin F, Carrera M, Coupland SE, Delbosc B, Ducrey N, Kantelip B, Kemeny JL, Meyer P, Sjo NC, Heegaard S. Primary lymphoma of the lacrimal sac: an EORTC ophthalmic oncology task force study Br J Ophthalmol 2006; 90: 1004-1009
