Eosinophilic granuloma of the skull bone: a case report Langenharns cell granulomatosis

Abstract

Eosinophilic granuloma is a rare benign tumor which is a variety of histiocytosis-X with unknown etiology. Eosinophilic granuloma occurs as single or multiple lesions of bone destruction. The eosinophilic granuloma of the skull can be asymptomatic or presented with pain and swelling. We present a clinical case of 20-years-old female patient who has entered the Neurosurgery clinic of “St. Marina” University Hospital with clinical manifestation of growing and painful tumor formation in the left frontal area for several weeks. MRI scan discovered evidence of a tumor formation on the left frontal side of the skull, suspicious for an eosinophilic granuloma. Under general anesthesia, an operative treatment was performed. Total extirpation of the tumor mass was achieved and cranioplasty with titanium mesh of the bone defect was performed. Posteratively, the patient had a good cosmetic effect, she was mobilized on the first day after the intervention and discharged from the hospital on the 5th day. Surgery-related complications were not observed. In the postoperative period the patient was followed-up by a hematologist. It is important and recommended for clinicians to include eosinophilic granuloma in the differential diganosis of bone lesions in patients because of the possible expansion of the disease if untreated. A follow-up of a year is necessary for possible recurrence.