Подходът за праг на тосикологична значимост (threshold of toxicological concern (TTC) е разработен, за да се оценяват веществата с неизвестна токсичност, които се срещат в храната в ниски нивa. Подходът за ТТС изисква единствено познаване на химическата структура на веществата и подходяща информация за човешката експозиция. ТТС концепцията е научната база на Прага на регулация (TOR), използван от Администрацията по храните и лекарствата на САЩ за индиректните хранителни добавки и материалите за контакт с храни. ТТС се използва от Експертния комитет ФАО/СЗО по хранителните добавки при оценката на ароматичните вещества.Според Научния комитет, ТТС може да бъде използван в работата на EFSA при оценката на онечистванията, разградните продукти и продуктите на реакции, метаболитите и замърсителите в ниски нивa в храната и фуражите, при които може да се оцени експозицията, но за които няма или има малко токсикологични данни. ТТС за дадено вещества трябва да се сравни с оценката за човешката експозиция на това химическо вещество, за да се определи дали има данни за безпокойство и дали са необходими по-задълбочени специфични за химическото вещество токсикологични данни.
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