Проучването обхваща 101 оперирани пациенти със синхронни чернодробни метастази от колоректален рак, 63% от които първично резектабилни. Установи се че полът, възрастта, локализацията на първичния тумор, размерът на тумора, Т стадият и G стадият не оказват статистически значимо влияние на преживяемостта. Значимо влияние имат: броят на чернодробните метастази, техния размер и разпределение, лимфоваскуларната инвазия и кръвозагубата. Оперираните, които не са носители на нито един от тези фактори имат 3 и 5 годишна преживяемост съответно 83% и 50%, тези с 1-2 фактора - 40% и 35%, а 14% от носителите на 3 и повече от тези фактори преживяват 3 години. Разликите между показателите в отделните групи са значими. Установяват се значими разлики в преживяемостта в зависимост от вида на хирургичната резекция - голяма или малка с носителство на различен брой от посочените фактори. Мнофакторният Кокс анализ потвърждава значението най-често на разпределението на чернодробните метастази и техния брой, наред с вида на чернодробната резекция. Не се намира значима разлика в преживяемостта при оперираните със синхронни и метахронни метастази. Резултатите от проучването могат да бъдат полезни за практиката, при вземане на решение за вида на хирургичната интервенция и последващото лечение
Gatta G, Capocaccia R, Sant M et al. (2000) Understanding variations in
survival for colorectal cancer in Europe: a EUROCARE study. Gut 47: 533-8
Manfredi S, Lepage C, Hatem C et al. (2006) Epidemiology and management
of liver metastases from colorectal cancer, Ann Surg 244:254-9
Beckurts K, Holscher A, Thorban S et al. (1997) Significance of lymph
node involvement at the hepatic hilum in the resection of colorectal liver
metastases. Br J Surg 84:1081-1084
Bolton J, Fuhrman G (2000) Survival after resection of multiple bilobar
hepatic metastases from colorectal carcinoma. Ann Surg 231:743-751
Choti M, Sitzmann J, Tiburi M et al. (2002) Trends in long term survival
following liver resection for hepatic colorectal metastases. Ann Surg
:759-66
De Santibanes E, Lassalle FB, McCormack L et al. (2002) Simultaneous
colorectal and hepatic resections for colorectal cancer: postoperative and
longterm outcomes. J Am Coll Surg 195:196-20
Doci R, Gennari L, Bignami P et al. (1995) Morbidity and mortality after
he patic resection of metastases from colorectal cancer. Br J Surg 82:377-81
Gayowski T, Iwatsuki S, Madariaga S et al. (1994) Experience in hepatic
resection of colorectal cancer - analysis of clinical and pathological risk
factors. Surgery 116: 703-71
Jaeck D, Bachellier P, Guiguet M et al. (1997) Association Francaise de
Chirurgie. Long-term survival following resection of colorectal hepatic
metastases. Br J Surg 84:977-980
Jamison R, Donohue J, Nagorney D et al. (1997) Hepatic resection for
metastatic colorectal cancer results in cure for ... Arch Surg 132:505-510
Minagawa M, Makuuchi M, Torzilli G et al. (2000) Extension of the frontiers
of surgical indications in the treatment of liver metastases from colorectal
cancer: long term results. Ann Surg 231:487-99
Nordlinger B, Guiguet M, Vaillant J et al. (1996) Surgical resection of colorectal
carcinoma metastases to liver. A prognostic scoring system to improve
case selection, based on 1568 patients. Cancer 77:1254-62
Ohlsson B, Stenram U, Tranberg K. (1998) Resection of colorectal liver
metastases: 25- year experience. World J Surg 22:268-276
Peeters K, Tollenaar R, Marijnen C et al. (2005) Dutch Colorectal Cancer
Group. Risk factors for anastomotic failure after total mesorectal excision
of rectal cancer. Br J Surg 92:211-6
Taylor M, Forster J, Langer B (1997) A study of prognostic factors for hepatic
resection for colorectal metastases Am J Surg 173:467-71
Vauthey J, Choti M, Helton W (2006) AHPBA/SSO/SSAT Consensus
Conference on hepatic colorectal metastases: ..., Jan 25, Ann Surg Oncol
Japanese gastric cancer association (1998) Japanese classification of gastric
carcinoma-2-nd edition. Gastric cancer 1:10-24
Ambiru S, Miyazaki M, Ito H et al. (1999) Adjuvant regional chemotherapy
after hepatic resection for colorectal metastases. Br J Surg 86:1025-1031
Jaeck D. (2003),The significance of hepatic pedicle lymph node metastases
in surgical management of colorectal liver metastases and of other liver
malignancies. Ann Surg Oncol 10:1007-11
Yazaki M, Ito H, Nakagava K et al. (1999) Aggressive surgical resection for
hepatic metastase involving the inferior vena cava. Am J Surg 177: 294-8
Coppa G, Eng K, Ranson J et al. (1985) Hepatic resection for metastatic
colon and rectal cancer. An evaluation of preoperative and postoperative
factors. Ann Surg 202:203-8
Bockhorn M, Frilling A, Fruhauf N et al. (2008) Survival of patients with
synchronous and metachronous colorectal liver metastases-is there a difference?
J Gastrointest Surg 12:1399-405
Minagawa M, Yamamoto J, Kosuge T et al. (2007) Simplified staging system
for predicting the prognosis of patients with resectable liver metastasis.
Arch Surg 142:269-76, discussion 277
Cady B, Stone M (1991) The role of surgical resection of liver metastases
in colorectal carcinoma. Semin Oncol 18:399-406
Iwatsuki S, Todo S, Starzl T (1988) Right trisegmentectomy with a synthetic
vena cava graft. Arch Surg 123:1021-226.
Scheele J, Stangl R, Altendorf-Hofmann A et al. (1991) Indicators of prognosis
after hepatic resection for colorectal secondaries. Surgery 110:13-29
Fong Y, Fortner J, Sun L et al. (1999) Clinical score for predicting recurrence
after hepatic resection for metastatic colorectal cancer: analysis of
consecutive cases. Ann Surg 230:309-318
Nordlinger B, Guiguet M, Vaillant J et al. (1996) Surgical resection of colorectal
carcinoma metastases to liver. A prognostic scoring system to improve
case selection, based on 1568 patients. Cancer 77:1254-62
Jaeck D, Bachellier P, Weber J et al. (1996) Surgical treatment of synchronous
hepatic metastases of colorectal cancers: simultaneous or delayed resection?
Ann Chir 50:507-512
Minagawa M, Yamamoto J, Miwa S et al. (2006) Selection criteria for simultaneous
resection in patients with synchronous liver metastasis. Arch
Surg 141:1006-12; discussion 1013
Fujita S, Akasu T, Moriya Y (2000) Resection of synchronous liver metastases
from colorectal cancer. Jpn J Clin Oncol 30:7-11
Taniai N, Yoshida H, Mamada Y et al. (2006) Outcome of surgical treatment
of synchronous liver metastases from colorectal cancer. J Nippon Med
Sch 73:82-8
Alberts S, Horvath W, Sternfeld W et al. (2005) Oxaliplatin, fluorouracil,
and leucovorin for patients with unresectable liver-only metastases from
colorectal cancer: NCCTG phase II study. J Clin Oncol 23(36): 9243-9
Fujita S, Akasu T, Moriya Y (2000) Resection of synchronous liver metastases
from colorectal cancer. Jpn J Clin Oncol 30:7-11
Ekberg H, Tranberg K, Andersson R et al. (1986) Determinants of survival
in liver resection for colorectal secondaries. Br J Surg 73:727-31
De Brauw L, De Velde C, Bouwhuis-Hoogerwerf M (1987) Diagnostic
evaluation and survival analysis of colorectal cancer patients with liver
metastases J Surg Oncol 34:81-6
Finan P, Marshall R, Cooper E et al. (1985) Factors affecting survival in
patients presenting with synchronous hepatic metastasisfrom colorectal
cancer: a clinical and computer analysis. Br J Surg 72:373-7
Doci R, Gennari L, Bignami P et al. (1991) One hundred patients with hepatic
metastases from colorectal cancer treated by resection: analysis of
prognostic determinants. Br J Surg 78:797- 80
Fortner J, Silva J, Golbey R et al. (1984) Multivariate analysis of a personal
series of 247 consecutive patients with liver metastases from colorectal
cancer. Treatment by hepatic resection. Ann Surg 199:306-16
