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Course of COVID-19 infection in hospitalized patients with diabetes mellitus - own experience

Dilyana Stoyanova, Nikola Kostadinov, Vladimir Gonchev

Abstract

Introduction: Infection with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is more severe in patients with diabetes mellitus (DM), especially in cases of type 2 diabetes (DMT2) - due to their older age, the high frequency of metabolic syndrome and related cardiovascular diseases (arterial hypertension, heart failure, ischemic heart disease), as well as due to the presence of micro- and macrovascular complications.

Objective: To investigate the relationship between COVID-19 infection and its severity in patients with diabetes mellitus.

Materials and methods: One-center retrospective study covering patients hospitalized in UMHAT Burgas AD, Burgas with a positive PCR test for SARS-CoV-2 infection, hospitalized from January 1 to January 31, 2021.

Results: The analysis included 368 patients with a mean age of 55 years, 62.3% of whom were male. During hospitalization, 73 patients died (19.8%). The most common concomitant diseases are diabetes mellitus (68.3%), obesity (42.6%) and hypertension (42.2%). Patients with diabetes mellitus had significantly higher mortality than those without diabetes mellitus, 22.3% and 14.1%, respectively (p = 0.04). Predictors of more severe course of SARS-CoV-2 infection in addition to gender, age and concomitant diseases are smoking, the presence of bilateral infiltrates, impaired renal function and accidental plasma glucose above 11.1 mmol / l.

Conclusion: The more severe course of SARS-CoV-2 infection in the diabetic population is probably due to older age, socio-economic factors, concomitant diseases, disorders of cell-mediated immunity. Patients with diabetes have an increased risk of death from any cause.


Keywords

Diabetes mellitus, SARS-CoV-2

Full Text


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DOI: http://dx.doi.org/10.14748/sm.v29i1.9048

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