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Age-related metabolic disturbances in adult patients with acute ischemic stroke

Daniela Yordanova Arabadzhieva, Zdravko Slavov, Vesela Zlateva, Ara Kaprelyan


INTRODUCTION. There is rising evidence of the role of hyperglycemia, hyperlipidemia and dyslipidemia in the etiopathogenesis of acute ischemic stroke (AIS). There is a considerable risk for AIS in adult individuals in advanced and senile age with these abnormalities. Our purpose was to reveal the incidence rate of the disorders of glucose and lipid metabolism in the adult patients with AIS.

Material and methods. We examined 129 male and 129 female AIS patients at a mean age of 71 years hospitalized in the First Clinic of Neurology, St. Marina University Hospital of Varna, in 2007-2013. The levels of blood glucose and of serum total cholesterol, triglycerides, HDL- and LDL-cholesterol at admission were examined. Statistical data processing was performed by variation (ANOVA as t-criterion was considered significant if p<0.05) and correlation (Pearson`s coefficient) analyses.

Results. Males aged ≤65 years and females aged 71-75 years presented with the highest mean blood glucose values. There are much more males with higher blood glucose concentrations than females aged ≤70 and 76-80 years. Both mean and maximal concentrations of total cholesterol were highest at the age 71-75 years, those of HDL-cholesterol - in males aged 66-70 years and those of LDL-cholesterol - in females aged 71-75 years. The differences between the mean levels of total cholesterol in males and females aged ≤65 years as well as those of LDL-cholesterol in males and females aged ≥81 years were statistically significant (p<0.01).

Conclusion. A regular control of the parameters of glucose and lipid metabolism in adults is necessary. Keeping-up individual`s healthy life-style could ensure a more effective AIS prevention.


acute ischemic stroke; age dependence; blood glucose; serum lipids

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About The Authors

Daniela Yordanova Arabadzhieva
Medical university of Varna

First clinic of neurology, Department of neurology, St. Marina university hospital of Varna

Zdravko Slavov
Department of informatics, Varna Free University

Vesela Zlateva
Medical university of Varna, Department of cardiology, St. Marina university hospital of Varna

Ara Kaprelyan
First clinic of neurology, Department of neurology, St. Marina university hospital of Varna

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