Introduction: Generalized eruptive syringomas is a rare clinical presentation of a benign adnexal tumor derived from the intraepidermal portion of the eccrine sweat ducts. Clinical presentation shows asymptomatic flesh-colored tumors on the anterior aspect of trunk.
Material and Methods: A case of 51-year-old male with a long-standing generalized eruption of multiple brown-colored papules, associated with odorous perspiration and total loss of teeth which appeared suddenly three years ago.
Results: Punch biopsy specimen revealed a normal epidermis overlying a dermis that was filled with multiple ducts embedded in a fibrous stroma. Тhe diagnosis of multiple syringomas was concluded. The perspiration odor was attributed to the presence of Gram-negative anaerobic bacteria.
Conclusion: Speculations on the possible common pathogenetic background are presented.
Patrizi A, Neri I, Marzaduri S, Varotti E, Passarini W. Syringoma: a review of twenty-nine cases. Acta Derm Venereol 1998; 78: 460-2.
Jacquet L, Darier J. Hiydradénomes éruptifs, épithéliomes adénoides des glandes sudoripares ou adénomes sudoripares. Ann Dermatol Syph 1887; 8: 317-23.
Goyal S, Martins CR. Multiple syringomas on the abdomen, thighs and groin. Cutis 2000; 66: 259-62.
Soler-Carrilo J, Estrach T, Mascaró JM. Eruptive syringoma: 27 new cases and review of the literature. J Eur Acad Dermatol Venereol 2001; 15:242- 6.
Mahnaz J, Mitra H, Parvin R. Generalized eruptive syringomas. Indian J Dermatol 2009; 54: 65-7.
Frazier CC, Camacho AP, Cockerell CJ. The treatment of eruptive syringoma in an African-American patient with a combination of trichloroacetic acid and CO2 laser destruction. Dermatol Surg 2001; 27(5): 489-92.
Fernández-Crehuet P, Herrera-Saval A, DomÃnguez-Cruz J, Camacho FM. Generalized Syringoma: A Case Study. Actas Dermosifiliogr 2007; 98(8): 575-6.
Friedman SJ, Butler DF. Syringoma presenting as milia.J Am Acad Dermatol 1987;16:310-4
Janninger CK, Brodkin RH. Eruptive syringomas. Cutis 1990; 46: 427-9.
Ambrojo P, Requena Caballero L, Aguilar Martinez A, Sánchez Yus E, Furió V. Clear-cell syringoma: Immunohistochemistry and electron microscopy study. Dermatologica 1989; 178: 164-6.
Guitart J, Rosenbaum M, Requena L. Eruptive syringoma: a misnomer for a reactive eccrine gland ductal proliferation? J Cutan Pathol 2003; 30(3): 202-5.
Draznin M. Hereditary syningomas: A case report. Dermatol Online J 2004; 10(2):19.
Berbis P, Fabre JF, Jancovici E, Privat Y. Benderitter T. Late-onset syringomas of the upper extremities associated with a carcinoidtumor. Arch Dermatol 1989; 125(6): 848-9.
Metze D, Wigbels B, Hildebrand A. Familial syringoma: A rare clinical variant. Hautarzt. 2001; 52(11): 1045-8.
Creamer D, Macdonald A, Briffiths WA. Unilateral linear syringomata. A case report. Clin Exp Dermatol 1999; 24(5): 428-30.
Al-Katma M, Bissada N, Bordeaux J, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol 2007; 13(3): 134-7.
Ogrendik M. Does periodontopathic bacterial infection contribute to the ethiopathogenesis of the autoimmune diasease rheumatoid arthritis? Discov Med 2012; 13(72): 349-55.
Stein J, Said Yekta S, Kleines M, OkD, Kasaj A, Reichert S, Schulz S, Scheithauer S. Failure to detect an association between aggressive periodontitis and the prevalence of herpesviruses. J Clin Periodontol 2013; 40(1): 1-7.
Email this article (Login required) 
