Abstract
DL-á-tocopherol acetate (TA) is a synthetic form of vitamin E, consisting of a mixture of eight diastereomers. The aim of the current study was to assess the influence of TA onplasma total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and triglycerides (TG) in rats fed a cholesterol-free standard diet (SD) and a 1% cholesterol-containing diet (ChD). TA was applied intraperitoneally for 30 days at doses of 25, 50 and 100 mg/kg. TA did not significantly influence plasma lipids of rats fed the SD. In rats fed the ChD the three doses of TA significantly prevented the dietary-induced increase of plasma TC and LDL-C. The HDL-cholesterol levels were not significantly influenced either by the ChD, or by the application of TA. The ChD induced a certain elevation of plasma TG while TA reduced their levels, the effect being significant at the highest TA dose. In conclusion, TA showed an antihyperlipidemic effect in rats with experimentally induced hyperlipidemia and could be valuable in reducing lipemia as a factor of cardiovascular risk.
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