Abstract
Hyper cholesterolemia and the resulting atherosclerosis has been a major problem for the past few decades. Adequate control of serum cholesterol levels is generally achieved by dietary modifications and/or drug regimens. However some patients, particularly those with familial hyper cholesterolemia, fail to respond. Additional treatment methods may be necessary to reduce LDL to safer levels in these individuals who are at high risk for atherosclerotic disease complications. Reduction of lipoproteins and Lp(a), of oxidation of LDL, improvement of the procoagulatory state and disturbed hemorheology associated with atherosclerosis, as well as the stabilization of plaques and the decrease of cytokines and adhesion molecules have been induced by apheresis and are thought to favorably influence regression of artherosclerosis.
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