Peripheral blood for the serum levels of NT-proBNP was taken from patients with STEMI before PCI and 24-48hours after the onset of the symptoms of myocardial infarction. Three of the samples from all 53 turned out to be positive to NT - proBNP concentration on Day 0. On day 1 there was a significant elevation of the positive samples 11 from 53 patients ( 20,7%) ( p = 0,01). All patients with STEMI and elevated serum levels of NT- proBNP have left ventricular ejection fraction <50%.
Our results imply that NT -proBNP level and its increase in the serum may be used as a biomarker for the severity of the ischemic heart disease.
Gaziano, T., et al., Cardiovascular Disease, in Disease Control Priorities in Developing Countries, D.T. Jamison, et al., Editors. 2006: Washington (DC).
Andersen, H.R., et al., A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med, 2003. 349(8): p. 733-42.
Boden, W.E., K. Eagle, and C.B. Granger, Reperfusion strategies in acute ST-segment elevation myocardial infarction: a comprehensive review of contemporary management options. J Am Coll Cardiol, 2007. 50(10): p. 917-29.
Keeley, E.C., J.A. Boura, and C.L. Grines, Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet, 2003. 361(9351): p. 13-20.
Morita, E., et al., Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction. Circulation, 1993. 88(1): p. 82-91.
Swedberg, K., et al., Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J, 2005. 26(11): p. 1115-40.
Nagaya, N., et al., Plasma brain natriuretic peptide is a biochemical marker for the prediction of progressive ventricular remodeling after acute myocardial infarction. Am Heart J, 1998. 135(1): p. 21-8.
Talwar, S., et al., Profile of plasma N-terminal proBNP following acute myocardial infarction; correlation with left ventricular systolic dysfunction. Eur Heart J, 2000. 21(18): p. 1514-21.
Groenning, B.A., et al., Detection of left ventricular enlargement and impaired systolic function with plasma N-terminal pro brain natriuretic peptide concentrations. Am Heart J, 2002. 143(5): p. 923-9.
Galvani, M., et al., N-terminal pro-brain natriuretic peptide on admission has prognostic value across the whole spectrum of acute coronary syndromes. Circulation, 2004. 110(2): p. 128-34.
Bazzino, O., et al., Relative value of N-terminal probrain natriuretic peptide, TIMI risk score, ACC/AHA prognostic classification and other risk markers in patients with non-ST-elevation acute coronary syndromes. Eur Heart J, 2004. 25(10): p. 859-66.
Kim, H., et al., Incremental prognostic value of C-reactive protein and N-terminal proB-type natriuretic peptide in acute coronary syndrome. Circ J, 2006. 70(11): p. 1379-84.
Szadkowska, I., et al., The relationship between early recanalization and serum NT-proBNP levels in patients with a first ST-segment elevation myocardial infarction treated with primary coronary angioplasty. Acta Cardiol, 2007. 62(5): p. 479-84.
Kashlov, J.K., et al., Serum levels of RIPK3 and troponin I as potential biomarkers for predicting impaired left ventricular function in patients with myocardial infarction with ST segment elevation and normal troponin I levels prior percutaneous coronary intervention. Biosci Trends, 2016. 10(4): p. 294-9.
Linkermann, A. and D.R. Green, Necroptosis. N Engl J Med, 2014. 370(5): p. 455-65.
Zhao, H., et al., Role of necroptosis in the pathogenesis of solid organ injury. Cell Death Dis, 2015. 6: p. e1975.
Email this article (Login required) 
