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Structural Changes in the Human Pineal Gland in Cases of Fibrosing Capsule

V. Dokov


The capsule and its trabeculae are an active element of the human pineal gland's structure. During the examination of section material we observed that in part if the pineal glands the capsule was thickened and with fibrosis (TFC). The literature review as well as our observations made us to undertake the current study with the aim tofind out what is the role of the thick and fibrotic capsule on the macroscopic characteristics and the main histologic structures of the human pineal gland. We studied 134 pineal glands taken from bodies of people who died from both non-violent and violent cause of death. 95 of the pineal glands were taken from men and 39 from women, with mean age 52,57 years. Slices 5 µ thick were stained with hematoxylin and eosin and Van Gieson. The material was examined on light microscope and results analyzed with standard statistical methods. Cases with TFC represent 43,08% of all studied pineal glands. There is no statistically significant difference in the percentage of cases with TFC between the groups of those who died at 20-39 years of age and 40 and above. There is no statistically significant difference in the percentage of cases with TFC among men and women. The length width and weight of pineal glands with fibrose capsulae are bigger. Density is not changed. The percentage with gliosis is higher in the group of pineal glands with gentle capsulae. The rest of the variables are without changes.


Human Pineal Gland; Fibrosing Capsule; Histology

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V. Dokov


V Dokov, Dept, of General and Clinical Pathology, Prof. P. Stoyanov Medical University of Varna, 55 Marin Drinov St, BG-9002 Varna

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