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Scripta Scientifica Medica

Acute generalized exanthematous pustulosis (AGEP): a literature review

Sonya Marina, Kristina Semkova, Dimitrina Guleva, Jana Kazandjieva


Acute generalized exanthematous pustulosis (AGEP) is a rare drug-induced pustular cutaneous reaction. The clinical course is characteristic with a sudden onset of multiple sterile pustules on an erythematous base with fever and neutrophilia, followed by a spontaneous resolution within two weeks. Drug-specific T cells play the main role in the pathogenesis, but the exact cytokine cascade and genetic background are yet to be elucidated. Timely and exact recognition is important in order to prevent confusion with infections and psoriasis and hence institution of unnecessary and wrong treatments. The diagnosis may be confirmed by typical history, identification of a culprit drug, histopathology and patch testing. The purpose of this review is to present the current knowledge on AGEP and its association with various drugs in the context of a drug allergic reaction.

Scripta Scientifica Medica 2013; 45(4): 7-12.

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About The Authors

Sonya Marina
Medical University of Sofia

Kristina Semkova
Medical University of Sofia

Dimitrina Guleva
Medical University of Sofia

Jana Kazandjieva
Medical University of Sofia

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