The teratogenic effect of the nootropic drugs Pyramem and Orocetam on the skeleton and internal organs of rats was investigated. Pregnant Wistar rats were treated orally by 200 mg/kg b. m. Pyramem and 200 mg/kg b. m. Orocetam during the period of organogenesis since the 7th until 15th day of pregnancy. The effect of these preparations on the fetuses in terms of malformations, skeletal fragility and abnormalities in the internal organs (lungs, liver, spleen and kidneys) close to delivery (day 20-21) was analyzed. The nootropics Orocetam and Pyramem failed to prove to be embryotoxic agents at all.
Белчева, А., П. Узунов. Фармакология. София, 1996, 176-177.
Koren, G., D. M. Zemlikis. Amer. J. Perinatol., 8, 1991,37-38.
Sturman, G., P. Freeman, A. R. Bailey, N. A. Seeley.^ge«Mc/(o/!5,38, 1993,C 185-C 187.
Sturman, G., P. Freeman, H. M. Meade. Hum. Experim. Toxicol, 13, 1994, 285.
Whitaker, J., К. M. Dix. Labor. Animals, 13, 1979, 309-310.
Email this article (Login required) 
