The authors shared their results from the validation in a guinea pig model of a new ossicular prosthesis with Targis/Vectris System (Ivoclar, Lichtenstein). During the previous two years, the biocompatibility of teflon, gold, and ceramics was assessed. The biocompatibility of Targis and Vectris materials does not exist anymore as they are used in dental practice since 9 years. Targis is a ceramic optimized polymer of the family of ceromers. Vectris is a high-technology material replacing the metal substructure. These materials were inserted into a new medium, in the middle ear of a guinea pig. The experiments were carried out for different periods of time - 29 days, 70 days and 260 days. The ossicular prostheses were histologically examined. Targis and Vectris implanted retroauricularily into guinea pig' middle ear cavity did not show any inflammatory- reaction signs when contacting the skin of the external auditory channel. They proved to be well biologically tolerated even after 260 days after implantation.
Ars, B . Tympano-ossicular allograft tympanoplasty. Benefits, ethical and forensic aspects.- In: Tran plants and Implants in Otology. M. Portmann, P. Boudard. D. Portmann, eds. Ml. Amsterdam, New York, Kluwer Publications, 1996, 121-126.
Austin, D. F . Vein graft tympanoplasty: two-year report.- Otolaryngol. Head Seek Surg., 67. 1963. 198-208.
Austin, D. F . Ossicular reconstruction.- Arch. 15. Otolaryngol.. 94. 1971, 525-535.
Begal, K... H. Zimmermann. Rekonstruktion der Gehorknochenkette mit Titan-lmplantaten.- Laiyngo-Rhino-Otologie, 79, 2000, 139-145.
Dormer. K . J . . G . E . B r y c e . J . V . D. Hough. Selection of biomaterials for middle and inner ear im- plants.- Otolaryngol. Clin. North Am., 28. 1995, No 1, 17-27.
Dost, P. H. Biomaterialen in der rekonstruktiven Mittelohrchirurgie.- In: 71. Jahresversammlung der Deutschen Gesellschaft fur Hals-Nasen-Ohren- Heilkunde, Kopf- und Hals-Chirurgie. - Lanugo- Rhino-Otologie, 79, 2000, Suppl. 2, S53-S72.
Emmetl, J . R. Biocompatible implants in tympanoplasty.- Am. J. Otol. 10. 1989. No 3, 215-219.
Goldenberg. R. A . Ossiculoplasty with composite prostheses: PORP and TORP.- Otolaryngol. Clin. North Am., 27, 1994, 727-745.
Harrison, W. H . , C. E . Shambaugh, J . Kaplan, E . L . D e r l a c k i . Prosthetics in the middle ear.- Arch. Otolaryngol.. 69, 1959, 661-666.
Harrison, W. H. Prosthetics in tympanoplasty.- Arch. Otolaryngol., 71, 1960, 437-442.
Hayden, G . D. Results with polyethylene T-strut in the restoration of hearing.- Laryngoscope, 71, 1961, 5054-5061.
Homsy, C. Biocompatibility in selection of materi- als for Implantation-,/ Biomed. Mater. Res., 4, 1970. 341-356.
House, H. P. Polyethylene in middle ear surgery.- Arch. Otolaiyngoi. 71, 1960, 926-931.
Jahnke, K . Reconstruction of the ossicular chain with bioinert ceramics.- In: Transplants and Implants in Otology. M. Portmann, P. Boudard. D. Portmann. eds. III. Amsterdam, New York, Kluwer Publications. 1996, 173-176.
Jahnke, K . . P. Dost, M. Schrader. Biocompatibility studies of implants for reconstructive middle ear surgery: scientific basis.- In: Transplants and Implants in Otology. M. Portmann, P. Boudard, D. Portmann, eds. III. Amsterdam. New York, Kluwer Publications. 1996.41-46.
Lehner, R . . C . Burkhardt, H. P. Zenner. Acoustic aspects of passive middle ear prostheses.- In: Transplants and Implants in Otology. M. Portmann, P. Boudard, D. Portmann, eds. I I I . Amsterdam, New York, Kluwer Publications, 1996, 177-180.
Merchant, S. N . , M. E . R a v i c z , S. E . Voss, W. T. Peake, J . J . Rossowski. Toynbee memorial lecture 1997. Middle ear mechanics in normal, diseased and reconstructed ears.- J. Laryngol. Otol.,112, 1998, 715-731.
Milkov, M., J . Staichev, G . Marinov. The first experiments with the materials Targis and Vectris for the ossicular prostheses production.- Set: Sci. Med. (Varna), 33, 2002, Suppl. I , p. 30.
Portmann, M., D. Portmann. Otologic surgery: Manual of oto-surgical techniques. San Diego and London. " S " Singular Publishing Group, Inc.
Schuring, A. G . , L . P. Berenholz, W. H. Lippy, F . M. Rizer, J . M. Burkey. Cavum major tympano-ossiculoplasty.- Am. J. Otol, 21, 2000, 306-309.
Shea, J . J . Tympanoplasty in chronic right otitis media: a case report.- Memphis Med.,33,1958,271-275.
Wullstein, H. Theory of practice of tympanoplasty.- Laryngoscope, 66, 1956, 1076-1093.
Zollner. I . Principles of plastic surgery of sound conducting apparatus.- J. Laryngol. Otol, 69, 1955, 637-652.
Email this article (Login required) 
