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Scripta Scientifica Medica


M. Zhelyazkova-Savova, S. Valcheva-Kuzmanova, D. K. Zhelyazkov


Isoteoline, a compound of aporphine structure, was studied for antidepressant activity. Two animal models were used: the behavioral despair test and the clonidine-induced hypothermia. Isoteoline failed to alter the immobility time in rats subjected to forced swimming, but antagonized the immobility-reducing effect of desipramine, both after a single and multiple administration. In rats made hypothermic by i.p. injection of clonidine, Isoteoline did not antagonize the effect on rectal temperature, but rather accentuated it. The conclusion was made that Isoteoline was devoid of antidepressant activity. The results were analyzed in terms of previously demonstrated interactions of Isoteoline with subtypes of serotonergic receptors and were found to provide further evidence in support of these interactions.


isoteoline; behavioral despair test; clonidine-induced hypothermia; antidepressant activity; rats

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M. Zhelyazkova-Savova

S. Valcheva-Kuzmanova

D. K. Zhelyazkov

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