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K. Hristozov, V. Nikolova, L. Koeva, P. Karatodorova


The problem of hyperprolactinaemia is a relatively new and the information regarding it is still controversial. The aim of the present investigation is to analyze a five-year experience of the Clinic of Endocrinology and Metabolic Diseases, Prof. Paraskev Stoyanov Medical University of Varna in this field. Eighty-six patients with high prolactin levels are analyzed: 81 females at a mean age of 32.4 years and 5 males at a mean age of 37.3 years. The patients are grouped as follows: 25 with prolactinomas, 23 with hypothalamic hyperprolactinaemia, 14 with empty sella syndrome, 6 with another hormone-secreting pituitary tumor, 4 with primary hypothyroidism and 5 with drug-induced hyperprolactinaemia. The diagnosis is based on clinical features, hormone levels, computer assisted tomography and magnetic resonance imaging. The main principles of treatment, their side effects and the results are discussed.


prolactinoma; hyperprolactinaemia; dopamin agonists; transsphenoidal adenomectomy; C T; MRJ

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K. Hristozov

V. Nikolova

L. Koeva

P. Karatodorova

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