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V. Madzhova, V. Madzhova, V. Tsaneva, M. Delijski


The data from a 10-years prospective study among 85 boys and 64 girls, mean age 14,1 ±3,8 years with mean diabetes duration 8,45 ±3,7 years are analyzed. Using a complex prospective screening we found the frequency of microalbuminuria (MAU) and estimated some parameters of progression of the renal damage. The patients were divided into 3 groups: no MAU, with MAU and with clinical signs of nephropathy. We traced the dynamics of glomerular fdtration, albumin excretion and arterial pressure. The effect of ACEIs was according to the level of proteinuria. In diabetics with macroalbuminuria a short-lasting effect run out to the end of the 2-nd year. In MAU-positive ptients ACEIs led to delay of nephropathy for 10-years in 86,48%, progression in 8,1% and regression to normoalbuminuria in 5,4%. In 15% of all the diabetics we found a significant raise of proteinuria. In 21,73% of patients with "borderline" albuminuria there was a progression after the 5-th year with a cumulative index 4,58% or 0,91%.


diabetes mellitus; diabetic nephropathy; microalbuminuria; glomerular filtration rate; adolescence

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Коев, Д. Клинична ендокринология. София, 1993, 269, 308-314.

Цанева, В. Епидемиология на захарния диабет и неговите усложнения в детската възраст. Докт. дис. Варна, МУ-Варна, 1998.

Ahmad, J . , М. A. Siddiqui, Н. Ahmad. Effective postponement of diabetic nephropathy with enalapril in normotensive type 2 diabetic pts with microalbuminuria.- Diabet. Care, 20, 1997, 1576-1581.

Bjorck, S., H. Mulec, S. Johnsen. Renal protective effect of enalapril in diabetic nephropathy .- BMJ, 304, 1992,339-343.

Ellis, D., C. Lloyd, D. J. Becker. The changing course of diabetic nephropathy: low density lipoprotein cholesterol and blood pressure correlate with regression of proteinuria.- Am. J. Kidney Dis., 27, 1996, No 6, 809-818.

Koeva, L , D. Koev. Epidemiology of diabetes mellitus in Bulgaria.- Biomed. Rev., 5, 1996, 57-63.

The Microalbuminuria Captopril Study Group. Captopril reduces the risk of nephropathy in IDDM patients with microalbuminuria.- Diabetologia, 39, 1996, No 5, 587-593.

Penno, G., N . Chaturvedi , et a I . Effect of A C E gene polymorphism on progression of renal disease and the influence of A C E inhibition in IDDM patients. Findings from the E U C L I D randomized controlled trial.- Diabetes, 47, 1998, 1507-1511.

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus.- Diabet. Care, 20, 1997, 1183-1197.

Rudberg, S., R. Osterby. Decreasing glomerular filtration rate-an indicator of more advanced diabetic glomerulopathy in the early course of microalbuminuria in IDDM adolescents?- Nephrol. Dial. Transplant., 12, 1997, No 6, 1149-1154.

Y i p , J. M. , S. L . Jones, M. J . Wiseman.Glomerular hyperfiltration in the prediction of nephropathy in IDDM: a 10-year follow-up study.- Diabetes, 45, 1996, No 12, 1729-1733.

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V. Madzhova

V. Madzhova

V. Tsaneva

M. Delijski

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