Routine treatment of of onychomycoses consists in single daily application of orungal (itraconazole)for 3-6 months. This study aims at assessing the effectiveness of orungal pulse therapy in onychomycoses of the hand. According to the new schedule, the drug is administered two times daily 2 capsules of 100 mg each for one week during three consecutive months. The effect of the pulse therapy in a female patient with onychomycosis of the hand after three months is excellent.The tolerability is good and there are no adverse effects at all.
Aditya Gupts et al. J. Amer. Acad. Dermatol, 39, 1998, N 2, 216-219.
Cauwenbergh, G. et al. J. Amer. Acad. Dermatol, 18, 1988, 263-268.
De Doncuer et al. Arch. Dermatol, 132, 1996, 34-41.
Еlewski, B. Clin. Courier, 12, 1994, No 9, 5-6.
Greer, G. Internal J. Dermatol, 34, 1995, No 8, 521-524.
Matthiew et al. Clin. Experim. Dermatol, 16, 1991, 374-376.
Meinhof, W. J. Amer. Acad. Dermatol, 29, 1993, No 1, 37-41.
Warnoc, D. W.J. Europ. Acad. Dermatol. VenereoL, 2, 1993, Suppl. 1, 19-28.
Willensen, M., et al. J. Amer. Acad. Dermatol, 26, 1992, 731-735.
Willensen, M. J. Europ. Acad. Dermatol. Venereol, 2, 1993, Suppl. 1, 6-11.