The authors examined the lung lesions caused by peroral aluminium application as a 0,1 % solution of AlСl3 in a dose of 3 mg Al3+/kg b. w. for 40 days in a total of 126 white male rats (70 experimental and 56 control). Visible structural alterations were established on the 15th day of the trial consisting in desquamation of bronchial epithelium, enhanced pmounts of acid glucosaminoglycans in the cell cytoplasm and irregular disposition of cells. Later on, the activity of SDH, alkaline phosphatase, and ATP-ase decreased but acid phosphatase activity increased. Connective-tissue fibres grew up in the wall of some bronchi. These morphological findings suggest that although perorally accepted, AlСl3 induced structural lesions in the lungs as well as metabolic disturbances in the bronchial mucosa which depended on the duration of treatment.
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