Polarographic investigations of the changed globular/fibrillar ratio in serum proteins under the influence of increasing zinc and copper ion concentrations in human blood serum were carried out. Very low concentrations of Zn2+ and Cu2+ did not exert any effect on the native globular structure of serum proteins at all. Some changes of the size and ratio of both polarographic waves could be detected at certain higher zinc and copper ion levels. This was considered a feature of structural alteration in some serum proteins. The results from the study allowed the estimation of optimal zinc and copper ion concentrations which did not exert any effect on the globular structure of the blood protein. The ions examined at these concentrations possessed a maximally favourable effect on the mechanisms in which they participated
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