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G. Bekyarova, I. Kozarev, T. Yankova


Standard thermal trauma of 3rda - 3rdb degree, of 15-20 per cent of body surface was induced on white male Wistar rats narcotized with thiopental The changes of the concentration of thioharhituric acid (TBA)- reactive products, the activity of some antioxidant enzymes such as superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G-6-PD), and catalase as well as the percentage of haemolysis were investigated during the early post-burn period (24, 48, and 72 hours after burning). It was demonstrated that erythrocyte haemolysis increased along with activation of lipid peroxidation (LPO) after thermic injury. Alpha-tocopherol treatment in a dose of 20 mg/kg body mass reduced the elevated levels of TBA-reactive products and enhanced erythrocytic antioxidant defence and resistance. It could be clarified that LPO activation played an important role in the haemolysis and that alpha-tocopherol stabilized erythrocyte membrane after burns.


Thermic injury; lipid peroxidation; alpha-tocopherol; erythrocytes; antioxidant enzymes; rats

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G. Bekyarova

I. Kozarev

T. Yankova

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