In recent years, colorectal surgery faces a series of challenges associated with the interdisciplinary approach in the biomedicine and clinical medicine of the new millennium. The Department of General and Operative Surgery at the Medical University `Professor Paraskev Stoyanov` of Varna has already organized 14 national conferences of coloproctology with rising international participation. The present jubilee Fifteenth International Congress of Colorectal Surgery represents the continuation of these conferences of coloproctology. It preserves the best practices and traditions and, in the same time, it traces the pathway to new innovations and scientific advances in this field of increasing socio-medical importance worldwide. It should be emphasized that these traditional conferences have substantially contributed to mutual exchange of experience and methodology as well as of theoretical and practical achievements between scientists and practitioners. It has considerably extended the interpersonal contacts and fruitful interrelations within the medical class and with the public as well.