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Metastatic colorectal cancer presenting with malignant pleural effsion - a self-experience study

Ivan Novakov


INTRODUCTION: Colorectal cancer (CRC) advanced stage (stage IVA) is characterized by distant metastasis in one organ or in one site. The aim of this study is to present a relatively rare localization of CRC dissemi­nation, i.e. pleural metastases clinically presenting with malignant pleural effusion.

PATIENTS AND METHODS: A total of 12 patients, 10 males and two females at a mean age of 61.4±13.3 years (range, 39-78 years) with malignant pleural effusion because of CRC were included in this four-year study (2012-2016). Physical examination and Karnofsky performance status score were evaluated. Radio­graphic studies were used to establish pleural effusion. Pleural effusion drainage and pleural fluid cytolog­ical examinations were performed. Patients` survival rate was established.

RESULTS: Pleural metastasis developed approximately 1.8±0.7 years after radical operation in all the pa­tients. Patient`s Karnofsky performance status score was ≤50. Pleural effusion evacuation was accomplished by tube thoracostomy in all the patients. The cytological examination established adenocarcinoma cells in the pleural effusion. The mean patient`s survival rate was 3.1±1.9 months.

CONCLUSION: This study described a rare localization of CRC metastasis in the pleural cavity character­ized by an extremely low patient`s survival rate. Scr Sci Med 2017; 49(3): 35-39


advanced colorectal cancer stage, malignant pleural effusion, tube thoracostomy, survival

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About The Author

Ivan Novakov
Department of Special Surgery, Medical University of Plovdiv

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