Scientific Online Resource System

Scripta Scientifica Medica

COLCHICINE IN THE THERAPY OF CARDIOVASCULAR DISEASE: THE BULGARIAN CONTRIBUTION

George N. Chaldakov

Abstract

Over the past decades, advances in the knowledge of colchicine about its  mechanisms of cellular actions have led to potential new uses for this very old drug. Here, I present briefly the Bulgarian contribution to possible potential of microtubule-disassembling agents (antitubulins), such as colchicine, in the therapy of various cardiovascular diseases such as atherosclerosis, atrial fibrillation, pericarditis, cardiac hypertrophy-associated heart failure, and systemic necrotizing vasculitis.

Keywords

colchicine, microtubules, antitubulins, cardiovascular disease, inflammation, fibrosis

Full Text


References

Chaldakov GN, Deyl Z, Vankov VN. Colchicine: possible new application of its antifibrotic (antisecretory) action. Physiol Bohemoslov. 1987;36(1):1-7.

Solak Y, Siriopol D, Yildiz A, Yilmaz MI, Ortiz A, Covic A, et al. Colchicine in renal medicine: New virtues of an ancient friend. Blood Purif. 2017;43(1-3):125-35. doi: 10.1159/000454669.

Chaldakov GN, Nikolov SD. Ultrastructure of the arterial smooth muscle cell. In: Wolf S, Werthessen NT, eds. The Smooth Muscle of the Artery. New York City, NY: Plenum Press. Adv Exp Med Biol 1975;57:14-20.

Chaldakov G, Nikolov S, Vankov V. Fine morphological aspects of the secretory process in arterial smooth muscle cells. II. Role of microtubules. Acta Morph Acad Sci Hung. 1977;25(2-3):167-74.

Chaldakov GN, Kadar A. Microtubules in arterial smooth muscle cells in vivo and in tissue culture. An electron microscope study. In: W. Hauss, R. Wissler, R. Lehman, eds. State of Prevention and Therapy of Human Arteriosclerosis and in Animal Models. Rheinisch-Westfalische Akademie der Wissenschaften, 1978, 211-31.

Chaldakov GN, Nikolov S, Vankov V. Can antitubuhns be antiatherosclerotic agents? A hypothesis based on electron microscope data. In: 6th Hungarian Atherosclerosis Conference. Dobogoko, 10-12.IX.1981. Abstracts, p. 11A.

Chaldakov GN. Antitubulins - a new therapeutic approach for atherosclerosis? Atherosclerosis. 1982;44(3):385-90.

Chaldakov GN, Vankov VN. Morphological aspects of secretion in the arterial smooth muscle cell, with special reference to the Golgi complex and microtubular cytoskeleton. Atherosclerosis. 1986;61(3):175-92.

Chaldakov GN, Vankov VN. Antifibrotic approach in the therapy of arterial occlusive diseases: new considerations. In: G. Trubestein, ed. Conservative Therapy of Arterial Occlusive Disease. Stuttgart and New York, Georg Thieme Verlag, 1986, 224-6.

Chaldakov GN, Grünwald J. Effect of colchicine on the ultrastructure of secretory-state smooth muscle cells from the rabbit artery wall. Exp Pathol. 1987;31(1):1-9.

Chaldakov GN, Nabika T, Nara Y, Yamori Y. Cyclic AMP- and cytochalasin B-induced arborization in cultured aortic smooth muscle cells: its cytopharmacological characterization. Cell Tissue Res. 1989;255(2):435-42.

Chaldakov GN. Anti-inflammatory drugs and ischemic heart disease: new considerations (a cell biologist`s proposal to cardiologists). J Am Coll Cardiol. 1991;17(6):1445-6.

Chaldakov GN. Proposal for clinical trials using anti-inflammatory drugs in the therapy of angina pectoris, myocardial infarction and coronary restenosis after angioplasty and bypass grafting. Med Hypotheses. 1992;37(2):74-5.

Yanev S, Fiore F, Hinev A, Ghenev PI, Hristova MG, Panayotov P, et al. From antitubulins to trackins. Biomed Rev. 2016;27:59-67.

Chaldakov GN, Kisheva AR, Ghenev P. Quo vadis, atherogenesis? Part 1. Smooth muscle cell secretion - may foe become friend in the fight against the vulnerable atherosclerotic plaque. Biomed Rev. 2017;28 (in press).

Vaidya K, Arnott C, Martínez GJ, Ng B, McCormack S, Sullivan DR, et al. Colchicine therapy and plaque stabilization in patients with acute coronary syndrome: A CT coronary angiography study. JACC Cardiovasc Imaging. 2017 Oct 14. doi: 10.1016/j.jcmg.2017.08.013.

Lennerz C, Barman M, Tantawy M, Sopher M, Whittaker P. Colchicine for prevention of post-cardiac procedure atrial fibrillation: Meta-analysis of randomized controlled trials. Int J Cardiol 2017;249:127-37. doi: 10.1016/j.ijcard.2017.08.039.

Salih M, Smer A, Charnigo R, Ayan M, Darrat YH, Traina M, et al. Colchicine for prevention of post-cardiac procedure atrial fibrillation: Meta-analysis of randomized controlled trials. Int J Cardiol 2017;243:258-262. doi: 10.1016/j.ijcard.2017.04.022.

Hemkens LG, Ewald H, Gloy VL, Arpagaus A, Olu KK, Nidorf M, et al. Cardiovascular effects and safety of long-term colchicine treatment: Cochrane review and meta-analysis. Heart. 2016;102(8):590-6. doi: 10.1136/heartjnl-2015-308542.

Lee JZ, Singh N, Howe CL, Low S-W, Huang JJ, Ortega G, et al. Colchicine for prevention of post-operative atrial fibrillation. JACC Clin Electrophysiol. 2016;2(1):78-85. doi: 10.1016/j.jacep.2015.09.016.

Campbell KB, Cicci TA, Vora AK, Burgess LD. Beyond gout: Colchicine use in the cardiovascular patient. Hosp Pharm. 2015;50(10):859-67. doi: 10.1310/hpj5010-859.

Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL. Low-dose colchicine for secondary prevention of cardiovascular disease. J Am Coll Cardiol. 2013;61(4):404-10. doi: 10.1016/j.jacc.2012.10.027.

Vogel RA, Forrester JS. Cooling off hot hearts: A specific therapy for vulnerable plaque? J Am Coll Cardiol. 2013;61(4):411-2. doi: 10.1016/j.jacc.2012.10.026.

Alsarah A, Alsara O, Laird-Fick HS. Cardiac manifestations of Familial Mediterranean fever. Avicenna J Med. 2017;7(4):158-63. doi: 10.4103/ajm.AJM_78_17.

Antonopoulos AS, Papanikolaou E, Vogiatzi G, Oikonomou E, Tousoulis D. Anti-inflammatory agents in peripheral arterial disease. Curr Opin Pharmacol. 2017;39:1-8. doi: 10.1016/j.coph.2017.11.001.

Cheng G, Kasiganesan H, Baicu CF, Wallenborn JG, Kuppuswamy D, Cooper G 4th. Cytoskeletal role in protection of the failing heart by β-adrenergic blockade. Am J Physiol Heart Circ Physiol. 2012;302(3):H675-87. doi: 10.1152/ajpheart.00867.2011.

Cheng G, Takahashi M, Shunmugavel A, Wallenborn JG, DePaoli-Roach AA, Gergs Y, et al. Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy. J Biol Chem. 2010;285(49):38125-40. doi: 10.1074/jbc.M110.148650.




DOI: http://dx.doi.org/10.14748/ssm.v49i4.4181
Array
Article Tools
Email this article (Login required)
About The Author

George N. Chaldakov
Medical University of Varna
Bulgaria

Department of Anatomy and Cell Biology

Font Size


|