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A comparative quantitative analysis of postnatal changes in cardiomyocites in normotensive and spontaneously hypertensive rats

G. Kotov, A. Iliev, B. Landzhov, L. Jelev, V. Kirkov, K. Savova, D. Hinova-Palova

Abstract

Differences between the size of cardiomyocytes from normotensive and hypertensive hearts have been studied by a small number of authors and have been limited to measurements of the cellular diameter, length and cross-sec­tional area. The aim of the present study was to analyse a broader range of morphometric markers in order to as­sess the size of the cardiac muscle cells and to compare the obtained data between normotensive Wistar rats and spontaneously hypertensive rats. Results were obtained by studying the hearts of 15 male normotensive Wistar rats, distributed in five age groups: 2 weeks old, 1, 3, 6, and 12 months old, each group containing three animals, as well as 6 spontaneously hypertensive rats, distributed in two age groups: 1 month old (young) and 6 months old (adult), each group containing three animals. With the advance in age, the thickness of the free wall of the ven­tricles and the cross-sectional area of cardiomyocytes from both ventricles increased, as did the cross-section­al area of cardiomyocytic nuclei. Conversely, a decrease in the cardiomyocytic density was noted. These chang­es were more pronounced in the left ventricle of both normotensive and spontaneously hypertensive rats but oc­curred at an earlier age and were better expressed in the group of spontaneously hypertensive rats. The morpho­metric markers analysed in the present study represent a statistically significant assessment, which illustrates the differences between hypertrophy and remodelling of the myocardium induced by advancing age under normo­tensive conditions and those initiated by arterial hypertension.





DOI: http://dx.doi.org/10.14748/ssm.v49i0.4818
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About The Authors

G. Kotov
Medical University of Sofia
Bulgaria

A. Iliev
Medical University of Sofia
Bulgaria

B. Landzhov
Medical University of Sofia
Bulgaria

L. Jelev
Medical University of Sofia
Bulgaria

V. Kirkov
Medical University of Sofia
Bulgaria

K. Savova
Medical University of Sofia
Bulgaria

D. Hinova-Palova
Medical University of Sofia
Bulgaria

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