According to recent studies, sterility has been growing progressively, and in about 40% of the cases infertility is caused by changes in spermatogenesis. Sterility does not endanger the physical health but it has an emotional impact on the personality and it influences negatively personal, interpersonal, social and professional attitudes. Of particular importance is the accurately developed spermogram and adequate treatment plan. Regardless of the continuously introduced new methods for diagnosing infertile patients, most of the factors influencing male sterility remain unclear. Between 40 and 50%, and according to some authors, up to 60% of male sterility is diagnosed as idiopathic, i.e. unsolved diagnosis. Increasingly, as a leading cause, the environmental effects of epigenetics are considered, causing an increase in oxidative stress in the sperm membrane, affecting the appearance of a gene without altering gene expression. The testicular form of Angiotensin-converting enzyme (ACE), one of the enzymes for which there are many phenotypic manifestations, has been established but it is difficult to test. The ACE activity has been shown to have a relation to the diagnosis of the causes leading to idiopathic infertility.
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