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Bioartificial organs

P. Valchanov


Organ transplantation has become an essential treatment option in a wide variety of clinical conditions. How­ever, millions of patients are waiting for lifesaving organs and the rise of chronic diseases only increases the de­mand. Also, allo- and xenotransplantations carry the risk of severe complications like rejection of the transplant­ed organ, side effects of the immunosuppressant medications and the risk of acquiring infections from the do­nors. Bioartificial organs combine the physical aspects of implantable prostheses with the biological advantages of organ transplantation. Enclosing live cells in a permissive, synthetic scaffold ensures immunoisolation, respec­tively avoids rejection by an immunologically incompatible host while the space limitation of the closed polymer capsule prevents overgrowth of the transplanted material. Currently, several types of bioartificial organs are be­ing actively developed, including kidney, pancreas, dopamine-secreting brain implants, ovaries, etc., giving hope to millions of patients, waiting for organ transplants.

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About The Author

P. Valchanov
Medical University of Varna

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