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Scripta Scientifica Medica

Angiotensin-converting enzymes - biochemical role and functional importance

Emilia Lakova, G. Krasteva

Abstract

This paper reviews the new data regarding angiotensin-converting enzyme(ACE) and its relatives. Somatic ACE, well known component of renin-angiotensin system (RAS), is membrane-bound metalloenzyme localized on endothelial cells. ACE converts angiotensin I (ANG I) to angiotensinII (ANG II)- potent vasoconstrictor. This enzyme is also involved in the catabolism of the vasodilator bradykinin and thus plays a dual role in the regulation of blood pressure, pathogenesis of arterial hypertension, and related cardiovascular disorders. ACE is enzyme of tissue RAS in brain, kidney, heart, blood vessels, adipose tissue, where it is responsible for local ANG II production. Testicular ACE is isozyme of ACE important for male fertility, insensitive to conventional ACE inhibitors.The newly discovered homolog of ACE, ACE2, has been expressed in the heart, kidney, testis, brain.This enzyme metabolizes ANG I to ANG-(1-9), and ANG II to vasodilator ANG-(1-7). ACE2 is not inhibited by "classical" ACE-inhibitors, and plays a critical role in regulating the balance between vasoconstrictor and vasdilator effects within the RAS cascade.

Scripta Scientifica Medica 2007; 39(1):7-9


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DOI: http://dx.doi.org/10.14748/ssm.v39i1.500
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About The Authors

Emilia Lakova
Medical University of Pleven
Bulgaria

Department of Biology and Pathophysiology

G. Krasteva
Medical University of Pleven
Bulgaria

Department of Experimental and Clinical Pharmacology

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