Pleural empyema is defined as an infection of the pleural space with the formation of purulent pleural fluid. As an empyema progresses, fibrosis of the pleural space develops. The pleural fibrosis represents the most debilitating aspect of empyema progression. As fibrosis increase, more invasive methods become necessary in treatment of empyema. The aim of this experimental study was to represent opportunities of the computed tomography (CT) in studying empyema progression, especially development of pleural fibrosis. Materials and Methods: Group of six `New-Zealand white` rabbits with induced right pleural empyema was used for this study. On 4th and 12th day of empyema progression, computed tomography of the animal`s thorax was performed. Quantitative Image Analysis (Densitometry) of the right pleural space was done. Results: The mean density value on 4th day was 21, 32(SD-1, 79) Hounsfield units (HU). The pathological changes on 12th day shown mean density value of 55, 43 (SD-2, 27) HU. The difference between values on 4th and 12th day were significant ( p<0,025). Discussion and conclusion: Densitometry changes in the pleural space, establishing with computed to mography, correlate with macroscopic and microscopic changes in empyeama progression. CT is a method for determine the pleural fibrosis in empyema progression. Experimental study confirmed the role of CT in practice for choosing the method of empyema`s treatment.
Scripta Scientifica Medica 2007; 39(1):71-75
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