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Drug-induced Rowell syndrome in a male patient

Vessel Kantardjiev, Elena Stoikova, Valentina Broshtilova


Rowell syndrome is a rare skin disease described as an association of erythema multiforme and systemic lupus erythematosus, immunologically characterized by speckled antinuclear, anti-Ro, and anti-La antibodies. The majority of described cases affect middle-aged women. We report a case of a 53-year-old man with no previous history of lupus erythematosus, who developed erythema multiforme-like lesions and immunological findings consistent with Rowell syndome upon an intake of non-steroidal anti-inflammatory drugs. The patient responded well to systemic steroids and hydroxychloroquine. A short overview, emphasizing the specific clinical, laboratory and histology findings of this peculiar syndrome, is also presented.


Rowell syndrome, lupus erythematosus, erythema multiforme

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About The Authors

Vessel Kantardjiev
Department of Dermatology and Venereology, Military Medical Academy, Sofia, Bulgaria

Elena Stoikova
Department of Dermatology and Venereology, Military Medical Academy, Sofia, Bulgaria


Valentina Broshtilova
Department of Dermatology and Venereology, Military Medical Academy, Sofia, Bulgaria Department of Infectious diseases, Parasitology and Dermatovenereology, Medical University "Prof. Dr Paraskev Stoyanov", Varna, Bulgaria



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