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Review on the pharmacological activities of lactoferricin and lactoferricin analogues

Dimana Dimitrova, Antonia Hristova, Momchil Lambev, Silvia Mihaylova, Tamara Paipanova, Stefka Valcheva-Kuzmanova


INTRODUCTION: Antimicrobial peptides (AMPs) are a growing class of natural and synthetic compounds with a wide spectrum of targets including viruses, bacteria, fungi, and parasites.

AIM: The aim of the present review was to make an overview of the available literature on the pharmacological activities of these peptides, focusing on lactoferricin and lactoferricin analogues.

MATERIALS AND METHODS: To achieve this aim, information from databases, such as PubMed, Google Scholar and ResearchGate was searched and summarized.

RESULTS: Antimicrobial peptides (AMPs) are considered a promising alternative to the antibiotics used nowadays. They have drawn a special attention in the fight against infections caused by antibiotic-resistant bacterial strains. Lactoferricin is the most studied AMP derived from milk protein. Lactoferricin (Lfcin) is a fragment of the ferro-chelate complex of the bovine protein lactoferrin (Lf). The amphipathic and cationic properties of Lfcin account for its broad spectrum antimicrobial activity. Lfcin also manifests potential antiviral, immunomodulatory, antitumor and anti-inflammatory properties. Shorter analogues of Lfcins have been synthesized with a broad spectrum of activities and enhanced pharmacokinetic properties.

CONCLUSION: Lactoferricin and its analogues are a good demonstration that it is possible to design and obtain synthetic peptides with enhanced pharmacological activities.


antimicrobial peptides; lactoferricin; lactoferricin activities; lactoferricin analogues

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About The Authors

Dimana Dimitrova
Medical University of Varna

Educational Sector Assistant Pharmacist, Medical College

Antonia Hristova
Medical University of Varna

Educational Sector Assistant Pharmacist, Medical College

Momchil Lambev
Medical University of Varna

Educational Sector Assistant Pharmacist, Medical College

Silvia Mihaylova
Medical University of Varna

Educational Sector Assistant Pharmacist, Medical College

Tamara Paipanova
Institute of Molecular Biology Acad. Roumen Tsanev, Bulgarian Academy of Sciences, Sofia

Stefka Valcheva-Kuzmanova
Medical University of Varna

Department of Pharmacology and Clinical Pharmacology and Therapeutics, Faculty of Medicine

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