Introduction: Obstructive sleep apnea syndrome (OSAS) is commonly associated with obesity, insulin resistance, metabolic syndrome, hypertension, and coronary artery disease. Irisin is a newly identified myokine and its serum concentration was found to be correlated with cardiac troponin and creatin kinase-MB in acute myocardial infarction patients. Furthermore, irisin levels were positively associated with endothelium-dependent vasodilation in type 2 diabetic patients.
Aim: In this study, we aimed to investigate serum irisin level in the newly diagnosed OSAS patients.
Materials and Methods: After obtaining ethical approval, 32 OSAS patients were included. All patients gave written informed consent. Diagnosis of OSAS was verified by an overnight polysomnography (PSG) and made by an apnea hypopnea index equal to or higher than 5. Venous blood samples were collected in the morning between 08.00 – 10.00 after PSG (n=25) or after one-night CPAP treatment (n=7). Serum irisin concentrations were studied by ELISA.
Results and Conclusion: Serum irisin concentrations were significantly higher in newly diagnosed OSAS group than in OSAS group after one night of CPAP treatment (199.7±42.4 vs 159.7±18.3 ng/mL respectively; p<0.01). These results suggest that increased serum irisin levels can be reduced by CPAP treatment and elevated serum irisin levels may be due to increased respiratory muscle activity and body temperature.
American Academy of Sleep Medicine. International classification of sleep disorders, 3rd ed. Darien, IL: American Academy of Sleep Medicine; 2014. p. 53-62.
Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008;5(2):136-43. doi: 10.1513/pats.200709-155MG.
Kent BD, Ryan S, McNicholas WT. Obstructive sleep apnea and inflammation: relationship to cardiovascular co-morbidity. Respir Physiol Neurobiol. 2011;178(3):475-81. doi: 10.1016/j.resp.2011.03.015.
Ozturk G, Yaprak M, Gurel EE, Ural K, Tuncer B, Ozturk L. Adipobiology of obstructive sleep apnea syndrome. Adipobiology. 2014;6:23-9.
Yüksel M, Okur HK, Pelin Z, Ogunc AV, Ozturk L. Arginase activity and nitric oxide levels in patients with obstructive sleep apnea syndrome. Clinics(Sao Paulo). 2014;69(4):247-52. doi: 10.6061/clinics/2014(04)05.
Aydin S, Aydin S, Kobat MA, Kalayci M, Eren MN, Yilmaz M, et al. Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology. Peptides. 2014;56:141-5. doi: 10.1016/j.peptides.2014.04.002.
Xiang L, Xiang G, Yue L, Zhang J, Zhao L. Circulating irisin levels are positively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical angiopathy. Atherosclerosis. 2014;235(2):328-33. doi: 10.1016/j.atherosclerosis.2014.04.036.
Zhu D, Wang H, Zhang J, Zhang X, Xin C, Zhang F, et al. Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nitrative stresses. J Mol Cell Cardiol. 2015;87:138-47. doi: 10.1016/j.yjmcc.2015.07.015.
Hou N, Han F, Sun X. The relationship between circulating irisin levels and endothelial function in lean and obese subjects. Clin Endocrinol. 2015;83(3):339-43. doi: 10.1111/cen.12658.
Pelin Z, Karadeniz D, Ozturk L, Gozukirmizi E, Kaynak H. The role of mean inspiratory effort on daytime sleepiness. Eur Respir J. 2003;21(4):688-94. DOI: 10.1183/09031936.03.00298903.
Aydin S, Aydin S, Kuloglu T, Yilmaz M, Kalayci M, Sahin I, et al. Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running. Peptides. 2013;50:13-8. doi: 10.1016/j.peptides.2013.09.011.
Calton EK, Soares MJ, James AP, Woodman RJ. The potential role of irisin in the thermoregulatory responses to mild cold exposure in adults. Am J Human Biol. 2013;28(5):699-704. doi: 10.1002/ajhb.22853.
Lim S, Honek J, Xue Y, Seki T, Cao Z, Andersson P, Yang X, et al. Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nat Protocol. 2012;7(3):606–15. doi: 10.1038/nprot.2012.013.
Hofmann T, Elbelt U, Stengel A. Irisin as a muscle-derived hormone stimulating thermogenesis – a critical update. Peptides. 2014;54:89-100. doi: 10.1016/j.peptides.2014.01.016.
Hins J, Series F, Almeras N, Tremblay A. Relationship between severity of nocturnal desaturation and adaptive thermogenesis: preliminary data of apneic patients tested in a whole-body indirect calorimetry chamber. Int J Obesity. 2006;30(3):574-7. doi: 10.1038/sj.ijo.0803159.
Li Y, Li X, Sun D, Cai S. Association of serum irisin concentrations with the presence and severity of obstructive sleep apnea syndrome. J Clin Lab Anal. 2016;31(5):1-5. doi:10.1002/jcla.22077.
Park KH, Zaichenko L, Brinkoetter M, Thakkar B, Sahin-Efe A, Joung KE, et al. Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab. 2013;98(12):4899-907. doi: 10.1210/jc.2013-2373.
Sesti G, Andreozzi F, Fiorentino TV, Mannino GC, Sciacqua A, Marini MA, et al. High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects. Acta Diabetol. 2014;51(5):705-13. doi: 10.1007/s00592-014-0576-0.
Bulcun E, Ekici M, Ekici A. Disorders of glucose metabolism and insulin resistance in patients with obstructive sleep apnoea syndrome. Int J Clin Pract. 2012;66(1):91-7. doi: 10.1111/j.1742-1241.2011.02795.x.
Cuhadaroglu C, Utkusavas A, Ozturk L, Salman S, Ece T. Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea. Lung. 2009;187(2):75-81. doi: 10.1007/s00408-008-9131-5.
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