The case history is described of a patient with chrornophobic adenoma of the hypophysis, as well as the light and electron microscopic findings.
Electron microscopic studies establish the presence of abundant secretory granules containing thyreotropic hormone and single granules with gonadotropic and somatotropic hormones.
The pathogenesis is discussed of the fundamental vegetative and endocrinic symptomatics - the adiposogenital syndrome and arterial hypertension in connection with the hormonal content of the adenoma, the jack of ovaries and the condition of the thyroid gland, as well as the connections between the hypothalamus and the hypophysis.
The importance is also discussed of impaired ovarial function and the thyroid, on the one hand, and the possibilities of a viral origin of the tumor, on the other.
Койнов, Р. Клиника на туморите в хипофизно-хипоталамичната област, София, 1960.
Fаrquhаr, М. G. Origin and fate of secretory granules in cells of the anterior pituitary, Trans. N. Y. Acad. Sci 23, 346, 1962.
Farquhar, M. Q. Fine structure and function in capillaries of the anterior pituitary gland. - Angiologia 12, 270, 1961.
Kamat, V. B. and all. The intracelhdar localization of hormonal activity in transplantable thyrotropin secreting pituitary tumors in mice. - J. Biophys. Biochem. Cytol.,
, 219, 1960.
Lever, L. D. et R. Peterson. Cellular identities in the pars distalis of the rat pituitary, Trans. N. Y. Acad. Sci 22, 504, 1960.
Lundin, P. M. and U. Schelin. Light and electron microscopical studies on the pituitary in stilbolxreated rats. - Acta path, et microbiol. scandinav. 54, 66, 1962.
Schelin, U. Chromophoba and acidophil adenomas of the human pituitary gland. - Acta pathol. et microbiol. scandinav., suppl. 158, 1962, Copenhagen.
Email this article (Login required) 
