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Dynamics of oxidative status in patients with paroxysmal atrial fibrillation

Mariya Negreva, Svetoslav Georgiev, Atanas Penev, Albena Alexandrova


Introduction: Studies have established oxidative disorders in persistent and permanent atrial fibrillation. Our aim was to investigate oxidative status still in the early hours of paroxysmal atrial fibrillation (PAF) and monitor its changes after sinus rhythm (SR) restoration.

Material and Methods: Levels of malondialdehyde and total glutathione were determined in plasma (Pl-MDA; Pl-GSH) and erythrocytes (Er-MDA; Er-GSH) together with erythrocyte glutathione peroxidase activity (GSH-Px) in 51 patients (59.84±1.6 years, 26 males). Markers were investigated upon hospital admission, 24 hours and 28 days after SR restoration. They were also determined in 52 healthy subjects (59.50±1.46 years, 26 males).

Results: Mean AF duration prior to hospitalization was 8.14±0.76 hours. Upon admission, Pl-MDA and Er-MDA were significantly increased (p<0.05; p<0.001), while Pl-GSH, Er-GSH and GSH-Px - decreased (p<0.001). Twenty four hours after rhythm conversion, changes in Er-MDA (p<0.001), Pl-GSH, Er-GSH and GSH-Px (p<0.05) were retained. On the 28th day, there was no significant difference in any of the markers (p>0.05).

Conclusion: Disorder of oxidative status is detected in the early hours of PAF, which persists after SR restoration. Oxidative balance is restored slowly with time. This specific dynamics of oxidative status is most likely related to AF clinical course, namely to its manifestation and recurrences.


atrial fibrillation; malondialdehyde; glutathione; glutathione peroxidase; sinus rhythm

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About The Authors

Mariya Negreva
Medical University of Varna

Department of Cardiology

Svetoslav Georgiev
Medical University of Varna

Department of Cardiology

Atanas Penev
Medical University of Varna

Associate Professor, Department of Cardiology

Albena Alexandrova
Bulgarian Academy of Science

Associate Professor, Laboratory of Free Radical Processes, Institute of Neurobiology

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