Scientific Online Resource System

Scripta Scientifica Medicinae Dentalis

The oral cavity- reservoir of infection with Helicobacter pylori

Miglena Stamboliyska, Klara Dokova, Sirma Angelova, Asiqna Koleva, Marieta Bazitova

Abstract

The oral cavity has been established as an entrance door and second ecological niche of Helicobacter pylori (HP). This question remains open - is the oral cavity a source of stomach infection or a cause of re-infection, recurrence or persistence of the infection? The aim of this study is to evaluate the frequency of HP infection into dental plaque and saliva on the base of performed screening, parallel and post-eradication investigation. In the context of this research the method of PCR has been implemented. In the course of the screening examination HP infection has been proved in 66% of all the cases. By the means of parallel investigation a combined infection has been confirmed in 62% of all the cases - presence of HP in the stomach and into the dental plaque. Concerning the HP infection into the dental plaque, it is in co-relation with both of the symptoms - periodontitis and halitosis. Taking into consideration these facts, we can conclude that oral cavity serves as a reservoir of infection, as well as a source for its tranfer into the stomach. Poor oral health status, including clinical findings of periodontitis and halitosis, have to be accepted as alarming markers for HP infection into the oral cavity and stomach. It is of great necessity for the patient to organize regular visits to the dentist for dental plaque control and tartar removal and maintenance of proper oral-dental condition as a measure of prevention of HP infection.


Keywords

Helicobacter pylori infection; oral cavity; prevalence; PCR; dental plaque; combined HP infection

Full Text


References

Stamboliyska M., Contemporary clinical-diagnostic and therapeutic aspects of the infection with Helicobacter pylori. [dissertation summary]. [Varna]: Medical University - Varna; 2014. Bulgarian.

Nabwera HM, Logan RP.Epidemiology of Helicobacter pylori: transmission, translocation and extragastric reservoirs. J Physiol Pharmacol. 1999;(5):711-722.

Song Q, Lange T, Spahr A, Adler G, Bode G. Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR. J Med Microbiol. 2000 Apr;49(4):349-53.

Hu W, Cao C, Meng H, Zhang J, Ma D, Zhang L. Detection and analysis of Helicobacter pylori in oral cavity and stomach from chronic gastritis patients. Zhonghua Yi Xue Za Zhi. 2002 Aug 10;82(15):1037-41. Chinese.

Gebara EC, Pannuti C, Faria CM, Chehter L, Mayer MP, Lima LA. Prevalence of Helicobacter pylori detected by polymerase chain reaction in the oral cavity of periodontitis patients. Oral Microbiol Immunol. 2004 Aug;19(4):277-80.

Kilmartin CM. Dental implications of Helicobacter pylori. J Can Dent Assoc. 2002 Sep; 68(2):489-93.

Siddiq M1, Haseeb-ur-Rehman, Mahmood A. Evidence of Helicobacter pylori infection in dental plaque and gastric mucosa. J Coll Physicians Surg Pak. 2004 Apr;14(4):205-7.

Kim N1, Lim SH, Lee KH, You JY, Kim JM, Lee NR, Jung HC, Song IS, Kim CY. Helicobacter pylori in dental plaque and saliva. Korean J Intern Med. 2000 Dec;15(3):187-94.

Panov Vl. Oral cavity- bio-system and eventual source of infectious substrate. dissertation summary]. [Varna]: 2010. Bulgarian.

Panov Vl, VL Boyanova, I Yanchev. Helicobacter pylori into oral cavity. Bulgarian Hepato-gastroenterology. 2006;2:29-32. Bulgarian.

Krasteva A, Kisselova A, Dineva V, Panov VE, Ivanova A, Krastev Z. Presence of helicobacter pylori in patients with oral malodor. J of IMAB. 2013 Jul-Dec;19(4):419-421.

Boyanova L. The role of lactobacillus as probiotics for prophylactic cares and therapy of Helicobacter pylori infection, literature review and personal preliminary investigations, Contemporary Medicine. 2004;5:27-32. Bulgarian.

Boyanova L, Panov Vl, Yordanov D, Gergova G, Mitov I, Characterization of oral Helicobacter pylori strain by four methods. Diagn Microbiol Infect Dis. 2013 Dec; 77(4):287-8.

Leung WK, Siu KL, Kwok CK, Chan SY, Sung R, Sung JJ. Isolation of Helicobacter Pylori from vomitus in children and its implication in gastro-oral transmission. Am J Gastroenterol. 1999 Oct;94(10):2881-4.

Krasteva A., Panov V., Krasteva A., Kisselova A. Oral cavity and systemic diseases - Helicobacter pylori and dentistry. Biotechnol & Biotechnol EQ. 2011;25:2447-541.

Leffler DA, Kelly CP, Green PH, Fedorak RN, DiMarino A, Perrow W, et al. Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. Gastroenterology. 2015 Jun;148(7):1311-9.e6




DOI: http://dx.doi.org/10.14748/ssmd.v1i2.1310

Refbacks

Article Tools
Email this article (Login required)
About The Authors

Miglena Stamboliyska
Medical University of Varna
Bulgaria

Faculty of Medicine
Department of Gastroenterology

Klara Dokova
Medical University of Varna

Faculty of Public Health, Department of Social Medicine and Health Care Organization

Sirma Angelova
Medical University of Varna

Faculty of Dental Medicine, Department of Pediatric Dentistry

Asiqna Koleva
Medical University of Varna

Faculty of Medicine
Department of Gastroenterology

Marieta Bazitova
Medical University of Varna
Bulgaria

Faculty of Dental Medicine

Font Size


|